Early thymocyte development is regulated by modulation of E2A protein activity.
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HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticityFactors and networks that underpin early hematopoiesisThe establishment of B versus T cell identityRegulation of pT alpha gene expression by a dosage of E2A, HEB, and SCLBcl11b is required for differentiation and survival of alphabeta T lymphocytesE proteins are required to activate germline transcription of the TCR Vbeta8.2 geneShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory diseaseId1 induces apoptosis through inhibition of RORgammat expressionHes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients.The origin and development of nonlymphoid tissue CD103+ DCs.Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development.Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis.Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient miceProgression of regulatory gene expression states in fetal and adult pro-T-cell development.E proteins and the regulation of early lymphocyte developmentAn essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cellsαβ versus γδ fate choice: counting the T-cell lineages at the branch point.The function of E- and Id proteins in lymphocyte development.Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiencyT-cell development and the CD4-CD8 lineage decision.Dynamic changes in E-protein activity regulate T reg cell development.Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage developmentTranscriptional and epigenetic networks of helper T and innate lymphoid cells.The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause acute T-lymphoid or myeloid leukemias in mice.Human T-cell leukemia virus type 1 Tax protein down-regulates pre-T-cell receptor alpha gene transcription in human immature thymocytesLeukaemia -- a developmental perspective.Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance.Decision checkpoints in the thymus.E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment.Helix-loop-helix proteins and lymphocyte development.Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors.T-cell development, doing it in a dish.Recent insights into the signals that control alphabeta/gammadelta-lineage fate.At the crossroads: diverse roles of early thymocyte transcriptional regulators.
P2860
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P2860
Early thymocyte development is regulated by modulation of E2A protein activity.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Early thymocyte development is regulated by modulation of E2A protein activity.
@en
type
label
Early thymocyte development is regulated by modulation of E2A protein activity.
@en
prefLabel
Early thymocyte development is regulated by modulation of E2A protein activity.
@en
P2093
P2860
P356
P1476
Early thymocyte development is regulated by modulation of E2A protein activity.
@en
P2093
P2860
P304
P356
10.1084/JEM.194.6.733
P407
P577
2001-09-01T00:00:00Z