Conformational instability of the cholera toxin A1 polypeptide
about
Ricin A chain insertion into endoplasmic reticulum membranes is triggered by a temperature increase to 37 {degrees}CModulation of toxin stability by 4-phenylbutyric acid and negatively charged phospholipidsA therapeutic chemical chaperone inhibits cholera intoxication and unfolding/translocation of the cholera toxin A1 subunitCytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1pStabilization of the tertiary structure of the cholera toxin A1 subunit inhibits toxin dislocation and cellular intoxicationDetection of toxin translocation into the host cytosol by surface plasmon resonance.Identification of host cell factors required for intoxication through use of modified cholera toxinGrape extracts inhibit multiple events in the cell biology of cholera intoxication.N-terminal extension of the cholera toxin A1-chain causes rapid degradation after retrotranslocation from endoplasmic reticulum to cytosolEndoplasmic reticulum calcium regulates the retrotranslocation of Trypanosoma cruzi calreticulin to the cytosol.Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol.The A subunit of Escherichia coli heat-labile enterotoxin functions as a mucosal adjuvant and promotes IgG2a, IgA, and Th17 responses to vaccine antigensContribution of subdomain structure to the thermal stability of the cholera toxin A1 subunit.Toxin instability and its role in toxin translocation from the endoplasmic reticulum to the cytosol.Host-Toxin Interactions Involving EspC and Pet, Two Serine Protease Autotransporters of the Enterobacteriaceae.ADP-ribosylation factor 6 acts as an allosteric activator for the folded but not disordered cholera toxin A1 polypeptide.Co- and post-translocation roles for HSP90 in cholera Intoxication.Uptake and processing of the cytolethal distending toxin by mammalian cells.Protein-disulfide isomerase displaces the cholera toxin A1 subunit from the holotoxin without unfolding the A1 subunitSubstrate-induced unfolding of protein disulfide isomerase displaces the cholera toxin A1 subunit from its holotoxin.Structural and functional interactions between the cholera toxin A1 subunit and ERdj3/HEDJ, a chaperone of the endoplasmic reticulum.A Conformational Shift in the Dissociated Cholera Toxin A1 Subunit Prevents Reassembly of the Cholera Holotoxin.Lipid rafts alter the stability and activity of the cholera toxin A1 subunit.Order-disorder-order transitions mediate the activation of cholera toxin.Thermal Unfolding of the Pertussis Toxin S1 Subunit Facilitates Toxin Translocation to the Cytosol by the Mechanism of Endoplasmic Reticulum-Associated Degradation.Animal Enterotoxigenic Escherichia coli.The Pneumocystis meiotic PCRan1p kinase exhibits unique temperature-regulated activityCholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum.Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins.Cholera: pathophysiology and emerging therapeutic targets.Host Cell Chaperones Hsp70/Hsp90 and Peptidyl-Prolyl Cis/Trans Isomerases Are Required for the Membrane Translocation of Bacterial ADP-Ribosylating Toxins.Structural characteristics of the plasmid-encoded toxin from enteroaggregative Escherichia coli.A novel mode of translocation for cytolethal distending toxin.Loss of 26S proteasome function leads to increased cell size and decreased cell number in Arabidopsis shoot organs.Cell Propagation of Cholera Toxin CTA ADP-Ribosylating Factor by Exosome Mediated Transfer.Protein disulfide isomerase does not act as an unfoldase in the disassembly of cholera toxin
P2860
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P2860
Conformational instability of the cholera toxin A1 polypeptide
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Conformational instability of the cholera toxin A1 polypeptide
@en
type
label
Conformational instability of the cholera toxin A1 polypeptide
@en
prefLabel
Conformational instability of the cholera toxin A1 polypeptide
@en
P2093
P2860
P1476
Conformational instability of the cholera toxin A1 polypeptide
@en
P2093
Abhay H Pande
Kathleen N Nemec
Michael Taylor
Patricia Scaglione
Randall K Holmes
Summer Tuthill
Suren A Tatulian
P2860
P304
P356
10.1016/J.JMB.2007.10.025
P407
P577
2007-10-16T00:00:00Z