about
Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells.Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan.Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxidesPeroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chainsHeparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan.Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammationHuman indoleamine 2,3-dioxygenase is a catalyst of physiological heme peroxidase reactions: implications for the inhibition of dioxygenase activity by hydrogen peroxide.Mammalian heme peroxidases: from molecular mechanisms to health implications.Oxidative damage to extracellular matrix and its role in human pathologies.Degradation of extracellular matrix and its components by hypobromous acid.Oxidation of heparan sulphate by hypochlorite: role of N-chloro derivatives and dichloramine-dependent fragmentation.Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates.Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations.Hypochlorite-mediated fragmentation of hyaluronan, chondroitin sulfates, and related N-acetyl glycosamines: evidence for chloramide intermediates, free radical transfer reactions, and site-specific fragmentation.Heparan sulfate degradation via reductive homolysis of its N-chloro derivatives.
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Martin D. Rees
@ast
Martin D. Rees
@en
Martin D. Rees
@es
Martin D. Rees
@nl
Martin D. Rees
@sl
type
label
Martin D. Rees
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Martin D. Rees
@en
Martin D. Rees
@es
Martin D. Rees
@nl
Martin D. Rees
@sl
prefLabel
Martin D. Rees
@ast
Martin D. Rees
@en
Martin D. Rees
@es
Martin D. Rees
@nl
Martin D. Rees
@sl
P106
P1153
7201512374
P21
P31
P496
0000-0002-3564-5736