Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner. - Wikidata - wikimedia - TriplyDB

Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner.

Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner.

http://www.wikidata.org/entity/Q41842355

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Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications EZH2 in normal hematopoiesis and hematological malignancies Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention Epigenetic regulation of hematopoietic stem cell aging The many faces of hematopoietic stem cell heterogeneity Endothelial Cell-Selective Adhesion Molecule Expression in Hematopoietic Stem/Progenitor Cells Is Essential for Erythropoiesis Recovery after Bone Marrow Injury EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent.Epigenetics in normal and malignant hematopoiesis: An overview and update 2017.ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis.Distinct stromal cell factor combinations can separately control hematopoietic stem cell survival, proliferation, and self-renewal.Engineering Hematopoietic Stem Cells: Lessons from Development.Concise review: hematopoietic stem cell aging and the prospects for rejuvenation Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.The molecular basis of myeloid malignancies.Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.Functional Crosstalk Between Lysine Methyltransferases on Histone Substrates: The Case of G9A/GLP and Polycomb Repressive Complex 2 Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2 Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease α-Globin as a molecular target in the treatment of β-thalassemia PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic stem and progenitor cells.EZH2 is increased in paediatric T-cell acute lymphoblastic leukemia and is a suitable molecular target in combination treatment approaches Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type.Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes.A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling Loss of Ezh2 cooperates with Jak2V617F in the development of myelofibrosis in a mouse model of myeloproliferative neoplasm.Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis.BRPF1 is essential for development of fetal hematopoietic stem cells Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury.Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression.Epigenetics of hematopoiesis and hematological malignancies.

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P2860

Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner.

http://www.wikidata.org/entity/Q41842355

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Polycomb repressive complex 2 ...... pmental-stage-specific manner.

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type

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Polycomb repressive complex 2 ...... pmental-stage-specific manner.

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Polycomb repressive complex 2 ...... pmental-stage-specific manner.

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J.STEM.2013.10.001

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Polycomb repressive complex 2 ...... pmental-stage-specific manner.

@en

P2093

Cong Peng

http://www.w3.org/2001/XMLSchema#string

Huafeng Xie

http://www.w3.org/2001/XMLSchema#string

Jessie H Hsu

http://www.w3.org/2001/XMLSchema#string

Jian Xu

http://www.w3.org/2001/XMLSchema#string

Minh Nguyen

http://www.w3.org/2001/XMLSchema#string

Stuart H Orkin

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Yuko Fujiwara

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P2860

BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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