Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria - Wikidata - wikimedia - TriplyDB

Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria

Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria

http://www.wikidata.org/entity/Q41842560

about

TMC207: the first compound of a new class of potent anti-tuberculosis drugs The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment?Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline.Oligomycin frames a common drug-binding site in the ATP synthase.Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase Bedaquiline as part of combination therapy in adults with pulmonary multi-drug resistant tuberculosis.Insights into the pharmacokinetic properties of antitubercular drugs.Potential novel antibiotics from HTS targeting the virulence-regulating transcription factor, VirF, from Shigella flexneri.atpE gene as a new useful specific molecular target to quantify Mycobacterium in environmental samples.Why is long-term therapy required to cure tuberculosis?New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria A high-throughput small-molecule screen to identify a novel chemical inhibitor of Clostridium difficile.A Review of the Evidence for Using Bedaquiline (TMC207) to Treat Multi-Drug Resistant Tuberculosis New drugs to treat multidrug-resistant tuberculosis: the case for bedaquiline Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue.In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas.New drugs against tuberculosis: problems, progress, and evaluation of agents in clinical development.Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase.Recent advances in antituberculous drug development and novel drug targets.New treatment options for multidrug-resistant tuberculosis.TMC207 becomes bedaquiline, a new anti-TB drug.Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis.Bedaquiline: a novel antitubercular agent for the treatment of multidrug-resistant tuberculosis.Bedaquiline for the treatment of drug-resistant tuberculosis.Management of drug resistantTB in patients with HIV co-infection.Drug Resistance Mechanisms in Mycobacterium tuberculosis.In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline.Simultaneous identification of mycobacterial isolates to the species level and determination of tuberculosis drug resistance by PCR followed by electrospray ionization mass spectrometry.In vitro activity of bedaquiline against rapidly growing nontuberculous mycobacteria.Development of new antituberculous agents based on new drug targets and structure-activity relationship.Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure.Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor.Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.Bedaquiline resistance: Its emergence, mechanism and prevention.Tomatidine, a lead antibiotic molecule that targets Staphylococcus aureus ATP synthase subunit C.

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P2860

Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria

http://www.wikidata.org/entity/Q41842560

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Genetic basis for natural and ...... noline R207910 in mycobacteria

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Antimicrobial Agents and Chemotherapy

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Genetic basis for natural and ...... noline R207910 in mycobacteria

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Aurelie Chauffour

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Emmanuelle Cambau

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Koen Andries

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Stephanie Petrella

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Vincent Jarlier

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Wladimir Sougakoff

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P2860

SWISS-MODEL: An automated protein homology-modeling server

Impact of genotypic studies on mycobacterial taxonomy: the new mycobacteria of the 1990s

Structure of Ala24/Asp61 --> Asp24/Asn61 substituted subunit c of Escherichia coli ATP synthase: implications for the mechanism of proton transport and rotary movement in the F0 complex

Solution structure of the transmembrane H+-transporting subunit c of the F1F0 ATP synthase

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

The rotary mechanism of ATP synthase.

An alternating least squares approach to inferring phylogenies from pairwise distances.

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