Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids.
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An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for ObesityOmega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade OverreactionsTracing the peopling of the world through genomicsMeta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians.PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c.Selection in Europeans on Fatty Acid Desaturases Associated with Dietary ChangesDiet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases.Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake.CanvasDB: a local database infrastructure for analysis of targeted- and whole genome re-sequencing projects.Human adaptation to arsenic-rich environments.Greenlandic Inuit show genetic signatures of diet and climate adaptation.A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring StudyAssociation between polymorphisms in the fatty acid desaturase gene cluster and the plasma triacylglycerol response to an n-3 PUFA supplementation.Consequences of essential fatty acids.FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissueSingle Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).Desaturase and elongase-limiting endogenous long-chain polyunsaturated fatty acid biosynthesis.Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight.Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic AcidFatty acid metabolism: Implications for diet, genetic variation, and disease.Microarray analysis of port wine stains before and after pulsed dye laser treatmentBrain white matter development is associated with a human-specific haplotype increasing the synthesis of long chain fatty acids.Archaic human genomics.Factors affecting breast milk composition and potential consequences for development of the allergic phenotype.The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults.Genetic signature of natural selection in first Americans.Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity.Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio.Purification and function analysis of the Δ-17 fatty acid desaturase with or without transmembrane domain.The importance of a balanced ω-6 to ω-3 ratio in the prevention and management of obesity.EPA and/or DHA? A test question on the principles and opportunities in utilizing the therapeutic potential of omega-3 fatty acids.TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases.Exome Sequencing Provides Evidence of Polygenic Adaptation to a Fat-Rich Animal Diet in Indigenous Siberian Populations.Polyunsaturated fatty acid biostatus, phospholipase A2 activity and brain white matter microstructure across adolescence.Dietary linoleic acid intake and blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials.Cross-sectional associations of cortical β-amyloid with erythrocyte membrane long-chain polyunsaturated fatty acids in older adults with subjective memory complaints.The distribution of three candidate cold-resistant SNPs in six minorities in North China.Δ-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators.Multiplex genomewide association analysis of breast milk fatty acid composition extends the phenotypic association and potential selection of FADS1 variants to arachidonic acid, a critical infant micronutrient.
P2860
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P2860
Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Genetic adaptation of fatty-ac ...... ega-3 and omega-6 fatty acids.
@en
type
label
Genetic adaptation of fatty-ac ...... ega-3 and omega-6 fatty acids.
@en
prefLabel
Genetic adaptation of fatty-ac ...... ega-3 and omega-6 fatty acids.
@en
P2093
P2860
P50
P1476
Genetic adaptation of fatty-ac ...... ega-3 and omega-6 fatty acids.
@en
P2093
Alan F Wright
Anna C V Johansson
Asa Johansson
Ben Oostra
Gerd Schmitz
Ghazal Zaboli
Harry Campbell
James F Wilson
Manuel A Rivas
P2860
P304
P356
10.1016/J.AJHG.2012.03.014
P407
P50
P577
2012-04-12T00:00:00Z