Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.
about
Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.The PIDDosome activates p53 in response to supernumerary centrosomes.Heterogeneity in sarcoma cell lines reveals enhanced motility of tetraploid versus diploid cells.Centrosomal clustering contributes to chromosomal instability and cancer.Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression.Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells.Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.Building the right centriole for each cell type.When E-cadherin is away, centrosomes can play.PLK4: a link between centriole biogenesis and cancer.Once and only once: mechanisms of centriole duplication and their deregulation in disease.Polo-like kinase 4 mediates epithelial-mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway.Novel STIL Compound Heterozygous Mutations Cause Severe Fetal Microcephaly and Centriolar Lengthening.Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma.Structural centrosome aberrations promote non-cell-autonomous invasiveness.The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis.Structural centrosome aberrations sensitize polarized epithelia to basal cell extrusionCentrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneityYLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect
P2860
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P2860
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年論文
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2015年論文
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2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
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2015年论文
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2015年论文
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2015年论文
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name
Over-expression of Plk4 induce ...... ssue hyperplasia in the mouse.
@en
type
label
Over-expression of Plk4 induce ...... ssue hyperplasia in the mouse.
@en
prefLabel
Over-expression of Plk4 induce ...... ssue hyperplasia in the mouse.
@en
P2093
P2860
P50
P356
P1433
P1476
Over-expression of Plk4 induce ...... issue hyperplasia in the mouse
@en
P2093
Christopher J Hindley
Joy Archer
Marta N Shahbazi
Paula A Coelho
Peri H Tate
Sam Wormald
William C Skarnes
P2860
P304
P356
10.1098/RSOB.150209
P577
2015-12-01T00:00:00Z