Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. - Wikidata - wikimedia - TriplyDB

Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

http://www.wikidata.org/entity/Q41880147

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AID and APOBECs span the gap between innate and adaptive immunity How to Define the Latent Reservoir: Tools of the Trade Barriers to a cure for HIV in women Controlling HIV-1: Non-Coding RNA Gene Therapy Approaches to a Functional Cure Challenges and Opportunities for T-Cell-Mediated Strategies to Eliminate HIV Reservoirs Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1 Impact of Chromatin on HIV Replication How Much HIV is Alive? The Challenge of Measuring Replication Competent HIV for HIV Cure Research Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street Very early combination antiretroviral therapy in infants: prospects for cure Studies of retroviral infection in humanized mice HIV-1 functional cure: will the dream come true?Dynamic models of viral replication and latency Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure Rational development of radiopharmaceuticals for HIV-1 Human immunodeficiency virus (HIV)-1 integration sites in viral latency Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting.Large Variations in HIV-1 Viral Load Explained by Shifting-Mosaic Metapopulation Dynamics Using animal models to overcome temporal, spatial and combinatorial challenges in HIV persistence research Where in the Cell Are You? Probing HIV-1 Host Interactions through Advanced Imaging Techniques Are T cells the only HIV-1 reservoir?Achieving HIV-1 Control through RNA-Directed Gene Regulation Bioinformatics and HIV latency.T cell engineering as therapy for cancer and HIV: our synthetic future Understanding HIV latency: the road to an HIV cure Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression Extremely High Mutation Rate of HIV-1 In Vivo Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV Residual Viremia in Treated HIV+ Individuals Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial Review: Influence of ART on HIV genetics Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1 Latency reversal and viral clearance to cure HIV-1.Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring.A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.Reduction of HIV persistence following transplantation in HIV-infected kidney transplant recipients Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

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Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

http://www.wikidata.org/entity/Q41880147

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2013 nî lūn-bûn

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2013年论文

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2013年论文

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2013年论文

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Replication-competent noninduc ...... ncrease barrier to HIV-1 cure.

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Replication-competent noninduc ...... ncrease barrier to HIV-1 cure.

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Replication-competent noninduc ...... ncrease barrier to HIV-1 cure.

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J.CELL.2013.09.020

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Replication-competent noninduc ...... increase barrier to HIV-1 cure

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Daniel I S Rosenbloom

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Janet D Siliciano

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Jeffrey Wang

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Joel N Blankson

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Jun Lai

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Liang Shan

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Nina N Hosmane

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The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1.

Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat

Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid

The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II

Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells

Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor

Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

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