Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH.
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Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion moleculeMatrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensisErythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitroAbnormal priming of CD4(+) T cells by dendritic cells expressing hepatitis C virus core and E1 proteins.Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis.Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats.Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasisTumorigenic and adhesive properties of heparanase.Anti-heparanase aptamers as potential diagnostic and therapeutic agents for oral cancer.Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1)Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.Heparanase is a host enzyme required for herpes simplex virus-1 release from cells.A liquid chromatography-mass spectrometry-based approach to characterize the substrate specificity of mammalian heparanase.Mammalian heparanase: what is the message?Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4.The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus.Microenvironmental and cellular consequences of altered blood flow in tumours.Contribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T.Heparanase expression is a prognostic indicator for postoperative survival in pancreatic adenocarcinomaHeparanase and autoimmune diabetes.Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase).Marine-derived oligosaccharide sulfate (JG3) suppresses heparanase-driven cell adhesion events in heparanase over-expressing CHO-K1 cells.Structures of five sulfated hexasaccharides prepared from porcine intestinal heparin using bacterial heparinase. Structural variants with apparent biosynthetic precursor-product relationships for the antithrombin III-binding site.NK cell heparanase controls tumor invasion and immune surveillance.Glomerular basement membrane heparan sulfate in health and disease: A regulator of local complement activation.Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation.Heparanase expression and function during early pregnancy in mice.Two heparanase splicing variants with distinct properties are necessary in early Xenopus development.T-lymphocyte interactions with endothelium and extracellular matrix.Heparan sulfate in immune responses.The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins.Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells.Human platelet heparanase: purification, characterization and catalytic activity.Evidence that platelet and tumour heparanases are similar enzymesMice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation
P2860
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P2860
Molecular behavior adapts to context: heparanase functions as an extracellular matrix-degrading enzyme or as a T cell adhesion molecule, depending on the local pH.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Molecular behavior adapts to c ...... le, depending on the local pH.
@en
type
label
Molecular behavior adapts to c ...... le, depending on the local pH.
@en
prefLabel
Molecular behavior adapts to c ...... le, depending on the local pH.
@en
P2093
P2860
P356
P1476
Molecular behavior adapts to c ...... le, depending on the local pH.
@en
P2093
Goldkorn I
Hershkoviz R
Vlodavsky I
P2860
P304
P356
10.1084/JEM.181.5.1929
P407
P577
1995-05-01T00:00:00Z