Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis.
about
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base bindingBiochemical and Structural Studies of the Mycobacterium tuberculosis O6-Methylguanine Methyltransferase and Mutated VariantsPoint mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.Insight into the cooperative DNA binding of the O⁶-alkylguanine DNA alkyltransferase.Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable proteinPeroxynitrite-dependent zinc release and inactivation of guanosine 5'-triphosphate cyclohydrolase 1 instigate its ubiquitination in diabetes.6-Carboxyfluorescein and structurally similar molecules inhibit DNA binding and repair by O⁶-alkylguanine DNA alkyltransferaseDNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability.Covalent capture of a human O(6)-alkylguanine alkyltransferase-DNA complex using N(1),O(6)-ethanoxanthosine, a mechanism-based crosslinker.A novel thermostable protein-tag: optimization of the Sulfolobus solfataricus DNA- alkyl-transferase by protein engineering.Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.Phosphorylation of methylated-DNA-protein-cysteine S-methyltransferase at serine-204 significantly increases its resistance to proteolytic digestion.Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase.Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase.
P2860
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P2860
Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Probing of conformational chan ...... states by limited proteolysis.
@en
type
label
Probing of conformational chan ...... states by limited proteolysis.
@en
prefLabel
Probing of conformational chan ...... states by limited proteolysis.
@en
P2093
P2860
P356
P1433
P1476
Probing of conformational chan ...... states by limited proteolysis.
@en
P2093
P2860
P304
P356
10.1042/BJ3290545
P407
P478
329 ( Pt 3)
P577
1998-02-01T00:00:00Z