Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening. - Wikidata - wikimedia - TriplyDB

Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.

Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.

http://www.wikidata.org/entity/Q41892145

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Insights into the channel gating of P2X receptors from structures, dynamics and small molecules Identification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains.A fluorescent approach for identifying P2X1 ligands A Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 Receptors Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gating Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors.The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel.Druggable negative allosteric site of P2X3 receptors.

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P2860

Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.

http://www.wikidata.org/entity/Q41892145

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2014 nî lūn-bûn

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A Dopychai

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G Schmalzing

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H Franke

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P2860

Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels.

Molecular and functional properties of P2X receptors--recent progress and persisting challenges

TMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channels

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Molecular physiology of P2X receptors

Modeller: generation and refinement of homology-based protein structure models

Identification of an intersubunit cross-link between substituted cysteine residues located in the putative ATP binding site of the P2X1 receptor

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5093-5112

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10.1111/BPH.12830

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22

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