Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
about
Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signalingAdvances in Autophagy Regulatory MechanismsSestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose TissueDNA Damage Response and Autophagy: A Meaningful PartnershipJanus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domainsThe GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome FunctionThe CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwaySestrin2 Suppresses Classically Activated Macrophages-Mediated Inflammatory Response in Myocardial Infarction through Inhibition of mTORC1 Signaling.Efficacy and Safety of Leucine Supplementation in the Elderly.Identification of an AMPK phosphorylation site in Drosophila TSC2 (gigas) that regulate cell growthGCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.Multiple amino acid sensing inputs to mTORC1.Sestrin regulation of TORC1: Is Sestrin a leucine sensor?Unsolved mysteries of Rag GTPase signaling in yeast.Biochemical Basis of Sestrin Physiological Activities.Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.Nutrient sensing and TOR signaling in yeast and mammals.Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian Cells.Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.The Architecture of the Rag GTPase Signaling Network.Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism.mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKα1 signaling.Drosophila melanogaster as a Model for Diabetes Type 2 Progression.
P2860
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P2860
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
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2015年论文
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name
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
@en
type
label
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
@en
prefLabel
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
@en
P2093
P2860
P356
P1433
P1476
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
@en
P2093
Haeli Park
Hwan-Woo Park
Ian A Semple
Jeong Sig Kim
Jun Hee Lee
Kun-Liang Guan
Myungjin Kim
Seung-Hyun Ro
Uhn-Soo Cho
P2860
P2888
P356
10.1038/SREP09502
P407
P577
2015-03-30T00:00:00Z