about
Early to late sparing of radiation damage to the parotid gland by adrenergic and muscarinic receptor agonistsMobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands.Cytokine treatment improves parenchymal and vascular damage of salivary glands after irradiation.Stem cell therapies for the treatment of radiation-induced normal tissue side effects.Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers.ΔNp73 enhances promoter activity of TGF-β induced genes.Oral sequelae of head and neck radiotherapy.Prevention and treatment of the consequences of head and neck radiotherapy.On the mechanism of salivary gland radiosensitivity.Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt SignalsRescue of salivary gland function after stem cell transplantation in irradiated glands.Stem cell therapy to reduce radiation-induced normal tissue damage.Current ideas to reduce or salvage radiation damage to salivary glands.Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers.The In Vitro Response of Tissue Stem Cells to Irradiation With Different Linear Energy Transfers.Cancer stem cells with increased metastatic potential as a therapeutic target for esophageal cancer.Similar ex vivo expansion and post-irradiation regenerative potential of juvenile and aged salivary gland stem cells.High and low LET radiation differentially induce normal tissue damage signals.Effects of Radioiodine Treatment on Salivary Gland Function in Patients with Differentiated Thyroid Carcinoma: A Prospective Study.Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands.TGFbeta-1 dependent fast stimulation of ATM and p53 phosphorylation following exposure to ionizing radiation does not involve TGFbeta-receptor I signalling.Radiation and transforming growth factor-beta cooperate in transcriptional activation of the profibrotic plasminogen activator inhibitor-1 gene.Purification and ex vivo expansion of fully functional salivary gland stem cells.Understanding mechanisms yields novel approaches to reduce radiotherapy-related xerostomia.Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer.Irradiation of rat brain reduces P-glycoprotein expression and function.Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat.Thalidomide ameliorates inflammation and vascular injury but aggravates tubular damage in the irradiated mouse kidney.Heterogeneity of prejunctional neuropeptide Y receptors inhibiting noradrenaline overflow in the portal vein of freely moving rats.Defects in muscarinic receptor-coupled signal transduction in isolated parotid gland cells after in vivo irradiation: evidence for a non-DNA target of radiation.Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland.Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials.Comparison of radiosensitivity of rat parotid and submandibular glands after different radiation schedules.Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension.Transforming growth factor-beta plasma dynamics and post-irradiation lung injury in lung cancer patients.Enhanced proliferation of acinar and progenitor cells by prophylactic pilocarpine treatment underlies the observed amelioration of radiation injury to parotid glands.Radioprotective effect of amifostine on parotid gland functioning is region dependent.Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment.Three-dimensional dose distribution for partial irradiation of rat parotid glands with 200kV X-rays.Loco-regional differences in pulmonary function and density after partial rat lung irradiation.
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Robert P. Coppes
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