The handling of the mechanistic probe 5-fluorouridine by the pseudouridine synthase TruA and its consistency with the handling of the same probe by the pseudouridine synthases TruB and RluA.
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The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologsPre-steady-state kinetic analysis of the three Escherichia coli pseudouridine synthases TruB, TruA, and RluA reveals uniformly slow catalysisRNA-guided isomerization of uridine to pseudouridine--pseudouridylation.Pseudouridine: still mysterious, but never a fake (uridine)!An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation.Pseudouridine in the Anticodon of Escherichia coli tRNATyr(QΨA) Is Catalyzed by the Dual Specificity Enzyme RluF.Archaeal proteins Nop10 and Gar1 increase the catalytic activity of Cbf5 in pseudouridylating tRNA.The Pseudouridine Synthases Proceed through a Glycal Intermediate.The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another.Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor.Unexpected linear ion trap collision-induced dissociation and Fourier transform ion cyclotron resonance infrared multi-photon dissociation fragmentation of a hydrated C-glycoside of 5-fluorouridine formed by the action of the pseudouridine synthasesRecent advances in synthetic approaches for medicinal chemistry of C-nucleosides.
P2860
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P2860
The handling of the mechanistic probe 5-fluorouridine by the pseudouridine synthase TruA and its consistency with the handling of the same probe by the pseudouridine synthases TruB and RluA.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The handling of the mechanisti ...... idine synthases TruB and RluA.
@en
type
label
The handling of the mechanisti ...... idine synthases TruB and RluA.
@en
prefLabel
The handling of the mechanisti ...... idine synthases TruB and RluA.
@en
P2093
P2860
P356
P1433
P1476
The handling of the mechanisti ...... ridine synthases TruB and RluA
@en
P2093
Eugene G Mueller
Junjun Chen
Marguerite K McDonald
Yizhou Xie
P2860
P304
P356
10.1021/BI101737Z
P407
P577
2010-12-29T00:00:00Z