Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway.
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Combating Tuberculosis Infection: A Forbidding ChallengeStructural and Biochemical Characterization of the Salicylyl-acyltranferase SsfX3 from a Tetracycline Biosynthetic PathwayBiosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediatesCharacterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis.Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics.Characterization of the amicetin biosynthesis gene cluster from Streptomyces vinaceusdrappus NRRL 2363 implicates two alternative strategies for amide bond formation.Characterization of LipL as a non-heme, Fe(II)-dependent α-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis.Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5'-O-sulfonamide moiety in Streptomyces sp. JCM9888.Mechanisms and structures of vitamin B(6)-dependent enzymes involved in deoxy sugar biosynthesis.Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics.The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE.Biosynthesis of albomycin δ(2) provides a template for assembling siderophore and aminoacyl-tRNA synthetase inhibitor conjugates.Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: discovery of an L-threonine:uridine-5'-aldehyde transaldolase.The muraminomicin biosynthetic gene cluster and enzymatic formation of the 2-deoxyaminoribosyl appendage.The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.Recent advances in the discovery and development of marine microbial natural products.Fe(II)-dependent, uridine-5'-monophosphate α-ketoglutarate dioxygenases in the synthesis of 5'-modified nucleosides.Antimicrobial nucleoside antibiotics targeting cell wall assembly: recent advances in structure-function studies and nucleoside biosynthesis.Recent derivatives from smaller classes of fermentation-derived antibacterials.Natural and engineered biosynthesis of nucleoside antibiotics in Actinomycetes.Nature's combinatorial biosynthesis and recently engineered production of nucleoside antibiotics in Streptomyces.Chemical logic and enzymatic machinery for biological assembly of peptidyl nucleoside antibioticsHeteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.Characterization of the sugar-O-methyltransferase LobS1 in lobophorin biosynthesis.Liquid chromatographic determination of CPZEN-45, a novel anti-tubercular drug, in biological samplesA new arylsulfate sulfotransferase involved in liponucleoside antibiotic biosynthesis in streptomycetes.Target-specific identification and characterization of the putative gene cluster for brasilinolide biosynthesis revealing the mechanistic insights and combinatorial synthetic utility of 2-deoxy-l-fucose biosynthetic enzymes.DNA affinity capturing identifies new regulators of the heterologously expressed novobiocin gene cluster in Streptomyces coelicolor M512.Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitorMechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein-protein interaction site in translocase MraY.Distribution of dTDP-glucose-4,6-dehydratase gene and diversity of potential glycosylated natural products in marine sediment-derived bacteria.Biosynthesis and regulation of secondary metabolites in microorganisms.Identification of mureidomycin analogues and functional analysis of an N-acetyltransferase in napsamycin biosynthesis.A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase.Identification of the gene cluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471.Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic.Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity.Characterization of Methyltransferase AlmCII in Chalcomycin Biosynthesis: The First TylF Family O-Methyltransferase Works on a 4'-Deoxysugar.Self-Resistance During Muraymycin Biosynthesis: A Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order.
P2860
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P2860
Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Identification and manipulatio ...... into the biosynthetic pathway.
@en
type
label
Identification and manipulatio ...... into the biosynthetic pathway.
@en
prefLabel
Identification and manipulatio ...... into the biosynthetic pathway.
@en
P2093
P2860
P356
P1476
Identification and manipulatio ...... into the biosynthetic pathway.
@en
P2093
Bernd Kammerer
Bertolt Gust
Emmanuel Wemakor
Leonard Kaysser
Liane Lutsch
Stefanie Siebenberg
P2860
P304
14987-14996
P356
10.1074/JBC.M901258200
P407
P577
2009-04-07T00:00:00Z