Complete but curtailed T-cell response to very low-affinity antigen
about
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in miceT Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T CellsNaïve T Cell Homeostasis Regulated by Stress Responses and TCR SignalingTCR Signaling in T Cell MemoryIdentifying Individual T Cell Receptors of Optimal Avidity for Tumor AntigensLower Affinity T Cells are Critical Components and Active Participants of the Immune ResponseThe role of naive T cell precursor frequency and recruitment in dictating immune response magnitudeTo affinity and beyond: harnessing the T cell receptor for cancer immunotherapyIndoctrinating T cells to attack pathogens through homeschoolingT cell responses to antigen: hasty proposals resolved through long engagementsDefining immune engagement thresholds for in vivo control of virus-driven lymphoproliferationDiacylglycerol Kinases in T Cell Tolerance and Effector FunctionRecent advances in T-cell engineering for use in immunotherapymicroRNAs function in CD8+T cell biologyBystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent mannerStrategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational StudyEcological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populationsNck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire.Role of CD8(+) T-cell immunity in influenza infection: potential use in future vaccine development.Stimulation of naive CD8+ T cells by a variant viral epitope induces activation and enhanced apoptosisFeedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number.Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity.Human naive and memory CD4+ T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells.HIV controller CD4+ T cells respond to minimal amounts of Gag antigen due to high TCR avidity.TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection.Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunityPredominant clonal accumulation of CD8+ T cells with moderate avidity in the central nervous systems of Theiler's virus-infected C57BL/6 mice.The Goldilocks model for TCR-too much attraction might not be best for vaccine designAttenuated T cell responses to a high-potency ligand in vivo.Stochastic models of lymphocyte proliferation and deathAssessment of bivalent and tetravalent dengue vaccine formulations in flavivirus-naïve adults in Mexico.Epitope density influences CD8+ memory T cell differentiation.Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responsesManipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE.Naturally occurring altered peptide ligands control Salmonella-specific CD4+ T cell proliferation, IFN-gamma production, and protective potency.Perspectives for computer modeling in the study of T cell activationPrimary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansionOne naive T cell, multiple fates in CD8+ T cell differentiation.Prolonged antigen presentation by immune complex-binding dendritic cells programs the proliferative capacity of memory CD8 T cells.
P2860
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P2860
Complete but curtailed T-cell response to very low-affinity antigen
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Complete but curtailed T-cell response to very low-affinity antigen
@en
type
label
Complete but curtailed T-cell response to very low-affinity antigen
@en
prefLabel
Complete but curtailed T-cell response to very low-affinity antigen
@en
P2093
P2860
P356
P1433
P1476
Complete but curtailed T-cell response to very low-affinity antigen
@en
P2093
Dietmar Zehn
Michael J Bevan
Sarah Y Lee
P2860
P2888
P304
P356
10.1038/NATURE07657
P407
P577
2009-01-28T00:00:00Z
P5875
P6179
1034171973