Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.

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(Immuno)proteasomes as therapeutic target in acute leukemia.Endoplasmic reticulum stress in the development of multiple myeloma and drug resistance.PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients

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Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.

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http://www.wikidata.org/entity/Q41907181

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.

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Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.

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Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.

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P1476

Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.

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P2093

Anders Sundan

http://www.w3.org/2001/XMLSchema#string

Anders Waage

http://www.w3.org/2001/XMLSchema#string

Glenn Buene

http://www.w3.org/2001/XMLSchema#string

Ida Johansson

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Katarzyna Baranowska

http://www.w3.org/2001/XMLSchema#string

Kristian K Starheim

http://www.w3.org/2001/XMLSchema#string

Kristine Misund

http://www.w3.org/2001/XMLSchema#string

Sagar Darvekar

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P2860

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Autophagy modulation as a potential therapeutic target for diverse diseases

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

New strategies in the treatment of multiple myeloma.

Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens.

Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies.

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70845-70856

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scholarly article

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10.18632/ONCOTARGET.12226

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English

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Geir Bjørkøy

Toril Holien

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2016-09-23T00:00:00Z

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27683126

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P921

hydroxychloroquine

P932

5342593

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Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.

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P2860

P2860

Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.

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