Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.
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The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of actionFerrocene-based antimalarialsAssessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure.Iron metallodrugs: stability, redox activity and toxicity against Artemia salinaSynthesis, structure and assessment of the cytotoxic properties of 2,5-dimethylazaferrocenyl phosphonates.Novel 4-aminoquinoline-pyrimidine based hybrids with improved in vitro and in vivo antimalarial activity.Lipophilic mediated assays for beta-hematin inhibitors.The antimalarial ferroquine: from bench to clinic.Ruthenium(II) arene complexes with chelating chloroquine analogue ligands: synthesis, characterization and in vitro antimalarial activity.1,2-disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents.In vitro and in vivo antischistosomal activity of ferroquine derivatives.Antimalarial compounds in Phase II clinical development.Organometallic anticancer compoundsAntimalarial aminothiazoles and aminopyridines from phenotypic whole-cell screening of a SoftFocus(®) library.Half-sandwich ruthenium–arene complexes with thiosemicarbazones: synthesis and biological evaluation of [(η⁶-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl complexesSynthesis, characterization, and antimicrobial evaluation of a small library of ferrocene-containing acetoacetates and phenyl analogs: the discovery of a potent anticandidal agent.Metalloprobes: synthesis, characterization, and potency of a novel gallium(III) complex in human epidermal carcinoma cellsEx vivo drug susceptibility of ferroquine against chloroquine-resistant isolates of Plasmodium falciparum and P. vivax.Pharmacokinetics of ferroquine, a novel 4-aminoquinoline, in asymptomatic carriers of Plasmodium falciparum infections.Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties.Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine.A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study.The global portfolio of new antimalarial medicines under development.Perspective: the potential of pyrazole-based compounds in medicine.Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Small organometallic compounds as antibacterial agents.Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials.Gold complexes as antimicrobial agents: an overview of different biological activities in relation to the oxidation state of the gold ion and the ligand structure.Enantiomeric-Enriched Ferrocenes: Synthesis, Chiral Resolution, and Mathematic Evaluation of CD-chiral Selector Energies with Ferrocene-Conjugates.Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics.Improved antiparasitic activity by incorporation of organosilane entities into half-sandwich ruthenium(II) and rhodium(III) thiosemicarbazone complexes.Structure-activity relationship of trifluoromethyl-containing metallocenes: electrochemistry, lipophilicity, cytotoxicity, and ROS production.Cytotoxic triosmium carbonyl clusters: a structure-activity relationship study.The antimalarial ferroquine is an inhibitor of hepatitis C virus.Effect of amide-triazole linkers on the electrochemical and biological properties of ferrocene-carbohydrate conjugates.Single dose treatment of malaria - current status and perspectives.Synthesis and biological activity of cymantrene and cyrhetrene 4-aminoquinoline conjugates against malaria, leishmaniasis, and trypanosomiasis.On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging.In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquineStructural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones.
P2860
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P2860
Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Synthesis and antimalarial act ...... errocene-chloroquine analogue.
@en
type
label
Synthesis and antimalarial act ...... errocene-chloroquine analogue.
@en
prefLabel
Synthesis and antimalarial act ...... errocene-chloroquine analogue.
@en
P2093
P356
P1476
Synthesis and antimalarial act ...... ferrocene-chloroquine analogue
@en
P2093
Brocard JS
Maciejewski LA
P304
P356
10.1021/JM970401Y
P407
P577
1997-11-01T00:00:00Z