Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins
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The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motifPoly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string searchSUMO1 modification of NF-kappaB2/p100 is essential for stimuli-induced p100 phosphorylation and processingPARP-1 transcriptional activity is regulated by sumoylation upon heat shockReal Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand BreaksInfected cell protein 0 functional domains and their coordination in herpes simplex virus replicationViral Mimicry to Usurp Ubiquitin and SUMO Host PathwaysPosttranslational modifications of proteins in the pathobiology of medically relevant fungiFunction and regulation of SUMO proteasesCentromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligasesRING domain dimerization is essential for RNF4 functionMechanism of ubiquitylation by dimeric RING ligase RNF4Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMOStructural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks.A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity.A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defenceKaposi's sarcoma-associated herpesvirus K-Rta exhibits SUMO-targeting ubiquitin ligase (STUbL) like activity and is essential for viral reactivationSUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damageThe Drosophila STUbL protein Degringolade limits HES functions during embryogenesis.SUMOylation inhibits FOXM1 activity and delays mitotic transition.SUMO modification regulates BLM and RAD51 interaction at damaged replication forks.In vivo modeling of polysumoylation uncovers targeting of Topoisomerase II to the nucleolus via optimal level of SUMO modificationSUMO chain formation is required for response to replication arrest in S. pombeDevelopment and validation of a method for profiling post-translational modification activities using protein microarrays.Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex.Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chainsSUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.Identification of small ubiquitin-like modifier substrates with diverse functions using the Xenopus egg extract system.Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.Role of SUMO:SIM-mediated protein-protein interaction in non-homologous end joining.An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.Cellular senescence and protein degradation: breaking down cancerDisruption of PML nuclear bodies is mediated by ORF61 SUMO-interacting motifs and required for varicella-zoster virus pathogenesis in skin.SUMOylation modulates the function of Aurora-B kinaseMultiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control.Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screenGold nanoparticles as a platform for creating a multivalent poly-SUMO chain inhibitor that also augments ionizing radiation.RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.
P2860
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P2860
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Conserved function of RNF4 fam ...... ligase to SUMOylated proteins
@en
type
label
Conserved function of RNF4 fam ...... ligase to SUMOylated proteins
@en
prefLabel
Conserved function of RNF4 fam ...... ligase to SUMOylated proteins
@en
P2093
P2860
P356
P1433
P1476
Conserved function of RNF4 fam ...... ligase to SUMOylated proteins
@en
P2093
Huaiyu Sun
Joel D Leverson
Tony Hunter
P2860
P304
P356
10.1038/SJ.EMBOJ.7601839
P407
P577
2007-08-30T00:00:00Z