Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation.
about
Identification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaKTargeting protein aggregation for the treatment of degenerative diseasesSynthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.Aggregation formation in the polyglutamine diseases: protection at a cost?Multiple discrete soluble aggregates influence polyglutamine toxicity in a Huntington's disease model systemConsensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Medical implications of understanding the functions of human small heat shock proteins.HMBA is a putative HSP70 activator stimulating HEXIM1 expression that is down-regulated by estrogen.Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70).Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.Candida albicans Is Resistant to Polyglutamine Aggregation and ToxicityHigh-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity.Direct assessment in bacteria of prionoid propagation and phenotype selection by Hsp70 chaperone.Pathways of cellular proteostasis in aging and disease.
P2860
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P2860
Pharmacological tuning of heat shock protein 70 modulates polyglutamine toxicity and aggregation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Pharmacological tuning of heat ...... mine toxicity and aggregation.
@en
type
label
Pharmacological tuning of heat ...... mine toxicity and aggregation.
@en
prefLabel
Pharmacological tuning of heat ...... mine toxicity and aggregation.
@en
P2093
P2860
P356
P1433
P1476
Pharmacological tuning of heat ...... mine toxicity and aggregation.
@en
P2093
AnaLisa Echeverria
Andrea D Thompson
Christopher G Evans
Gladis M Walter
Jason E Gestwicki
Leah N Makley
Martin L Duennwald
Sidhartha M Chafekar
Susanne Wisén
P2860
P304
P356
10.1021/CB300166P
P577
2012-06-22T00:00:00Z