In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2

In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2

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http://www.wikidata.org/entity/Q41958792
Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteinsEpistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening.Computational design of selective peptides to discriminate between similar PDZ domains in an oncogenic pathwayLocating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins.Enriching Peptide Libraries for Binding Affinity and Specificity Through Computationally Directed Library Design.Biophysical basis of the promiscuous binding of B-cell lymphoma protein 2 apoptotic repressor to BH3 ligands.Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.Molecular determinants of the binding specificity of BH3 ligands to BclXL apoptotic repressor.After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.Escherichia coli Quorum-Sensing EDF, A Peptide Generated by Novel Multiple Distinct Mechanisms and Regulated by trans-Translation.Rational, computer-enabled peptide drug design: principles, methods, applications and future directions.Structure-Based Identification of HDAC8 Non-histone SubstratesDesigned BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.Association between glucose-regulated protein and neutrophil apoptosis in severe acute pancreatitis.Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models.
P2860

In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2

Item
http://www.wikidata.org/entity/Q41958792
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2
@en
type
label
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2
@en
prefLabel
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P932