Mutation in MTO1 involved in tRNA modification impairs mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae
about
Modification of the wobble uridine in bacterial and mitochondrial tRNAs reading NNA/NNG triplets of 2-codon boxesThe flavoproteome of the yeast Saccharomyces cerevisiaeMTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitroCombination of the loss of cmnm5U34 with the lack of s2U34 modifications of tRNALys, tRNAGlu, and tRNAGln altered mitochondrial biogenesis and respiration.Toward understanding the genetic basis of adaptation to high-elevation life in poikilothermic species: a comparative transcriptomic analysis of two ranid frogs, Rana chensinensis and R. kukunoris.Mechanistic study on the nuclear modifier gene MSS1 mutation suppressing neomycin sensitivity of the mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiaeMTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.MTO1 worked as a modifier in the aminoglycosides sensitivity of yeast carrying a mitochondrial 15S rRNA C1477G mutationMutations of the mitochondrial-tRNA modifier MTO1 cause hypertrophic cardiomyopathy and lactic acidosis.
P2860
Q26998594-094F907B-5E81-41A3-9200-48081D589C18Q27021669-9711D122-0C2A-48E0-A209-F695D64A7FE5Q27320993-87C3FA31-BE70-4F05-976B-D350015375C1Q28596353-73FA1BBE-F744-4FCF-98CB-4641F805E4BDQ33638916-0B69EE8B-5172-4F29-85E9-40D9793655A3Q34463670-4B9A6D23-C63E-4969-A530-0912A4F14775Q35111034-F22E83DE-112E-4B42-803D-D996D5C8B345Q35234097-3EBB4916-2A9D-4405-BFDC-0AAD821057C4Q35610774-82691119-53EA-49E9-8563-963E85D75482Q41836048-54B86BC4-1839-4165-8C2C-7CE5B5A59FCF
P2860
Mutation in MTO1 involved in tRNA modification impairs mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Mutation in MTO1 involved in t ...... yeast Saccharomyces cerevisiae
@en
type
label
Mutation in MTO1 involved in t ...... yeast Saccharomyces cerevisiae
@en
prefLabel
Mutation in MTO1 involved in t ...... yeast Saccharomyces cerevisiae
@en
P2093
P2860
P1433
P1476
Mutation in MTO1 involved in t ...... yeast Saccharomyces cerevisiae
@en
P2093
Min-Xin Guan
Qingfeng Yan
Xinjian Wang
P2860
P304
P356
10.1016/J.MITO.2009.01.010
P577
2009-01-30T00:00:00Z