Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.
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Mutations in the RNA granule component TDRD7 cause cataract and glaucomaDIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteinsCharacterization of SMOC-2, a modular extracellular calcium-binding proteinFunctional analysis of an arthritogenic synovial fibroblastFunctional analysis of human hematopoietic stem cell gene expression using zebrafish.On the evolutionary relationship between chondrocytes and osteoblastsSPARC, a matricellular glycoprotein with important biological functionsDeficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ miceThe role of astrocyte-secreted matricellular proteins in central nervous system development and functionRequirement for the c-Maf transcription factor in crystallin gene regulation and lens development.Identification of novel cell-adhesion molecules in peripheral nerves using a signal-sequence trapTumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancerIdentification of pax6-dependent gene regulatory networks in the mouse lens.SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice.Increased expression of osteonectin/SPARC mRNA and protein in age-related human cataracts and spatial expression in the normal human lens.Matricellular proteins in the trabecular meshwork: review and update.Secreted protein acidic and rich in cysteine is a matrix scavenger chaperone.Osteonectin/SPARC secreted by RPE and localized to the outer plexiform layer of the monkey retina.Cat-Map: putting cataract on the mapIdentification and functional clustering of global gene expression differences between age-related cataract and clear human lenses and aged human lenses.Molecular genetics of age-related cataract.Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome.The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity.Matricellular proteins as modulators of cell-matrix interactions: adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2.SPARC-null mice exhibit increased adiposity without significant differences in overall body weight.Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC.Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis.Molecular characterization of mouse lens epithelial cell lines and their suitability to study RNA granules and cataract associated genesMatricellular proteins in cardiac adaptation and disease.FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weaknessRecessive osteogenesis imperfecta caused by missense mutations in SPARC.Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials.High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Effects of bone matrix proteins on fracture and fragility in osteoporosis.Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinomaMyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alphaRole of long non-coding RNA MIAT in proliferation, apoptosis and migration of lens epithelial cells: a clinical and in vitro study.Signal transduction of lipopolysaccharide-induced osteoclast differentiation.Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.Is SPARC an evolutionarily conserved collagen chaperone?
P2860
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P2860
Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Mice deficient for the secrete ...... on and disruption of the lens.
@en
type
label
Mice deficient for the secrete ...... on and disruption of the lens.
@en
prefLabel
Mice deficient for the secrete ...... on and disruption of the lens.
@en
P2093
P2860
P356
P1433
P1476
Mice deficient for the secrete ...... on and disruption of the lens.
@en
P2093
D T Gilmour
J M Cunningham
J R Anderson
M B Carlton
W H Colledge
P2860
P304
P356
10.1093/EMBOJ/17.7.1860
P407
P577
1998-04-01T00:00:00Z