Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. - Wikidata - wikimedia - TriplyDB

Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.

Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.

http://www.wikidata.org/entity/Q41974331

about

Mutations in the RNA granule component TDRD7 cause cataract and glaucoma DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins Characterization of SMOC-2, a modular extracellular calcium-binding protein Functional analysis of an arthritogenic synovial fibroblast Functional analysis of human hematopoietic stem cell gene expression using zebrafish.On the evolutionary relationship between chondrocytes and osteoblasts SPARC, a matricellular glycoprotein with important biological functions Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice The role of astrocyte-secreted matricellular proteins in central nervous system development and function Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.Identification of novel cell-adhesion molecules in peripheral nerves using a signal-sequence trap Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer Identification of pax6-dependent gene regulatory networks in the mouse lens.SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice.Increased expression of osteonectin/SPARC mRNA and protein in age-related human cataracts and spatial expression in the normal human lens.Matricellular proteins in the trabecular meshwork: review and update.Secreted protein acidic and rich in cysteine is a matrix scavenger chaperone.Osteonectin/SPARC secreted by RPE and localized to the outer plexiform layer of the monkey retina.Cat-Map: putting cataract on the map Identification and functional clustering of global gene expression differences between age-related cataract and clear human lenses and aged human lenses.Molecular genetics of age-related cataract.Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome.The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity.Matricellular proteins as modulators of cell-matrix interactions: adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2.SPARC-null mice exhibit increased adiposity without significant differences in overall body weight.Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC.Absence of host-secreted protein acidic and rich in cysteine (SPARC) augments peritoneal ovarian carcinomatosis.Molecular characterization of mouse lens epithelial cell lines and their suitability to study RNA granules and cataract associated genes Matricellular proteins in cardiac adaptation and disease.FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness Recessive osteogenesis imperfecta caused by missense mutations in SPARC.Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials.High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Effects of bone matrix proteins on fracture and fragility in osteoporosis.Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha Role of long non-coding RNA MIAT in proliferation, apoptosis and migration of lens epithelial cells: a clinical and in vitro study.Signal transduction of lipopolysaccharide-induced osteoclast differentiation.Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.Is SPARC an evolutionarily conserved collagen chaperone?

P2860

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P2860

Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens.

http://www.wikidata.org/entity/Q41974331

description

1998 nî lūn-bûn

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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1998年论文

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1998年论文

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name

Mice deficient for the secrete ...... on and disruption of the lens.

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type

label

Mice deficient for the secrete ...... on and disruption of the lens.

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prefLabel

Mice deficient for the secrete ...... on and disruption of the lens.

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P1433

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P2860

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P1433

The EMBO Journal

P1476

Mice deficient for the secrete ...... on and disruption of the lens.

@en

P2093

B L Hogan

http://www.w3.org/2001/XMLSchema#string

D T Gilmour

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G J Lyon

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J M Cunningham

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J R Anderson

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J R Sanes

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M B Carlton

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M J Evans

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W H Colledge

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P2860

Osteonectin, a bone-specific protein linking mineral to collagen

Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors

The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform

SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix

Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

A low-viscosity epoxy resin embedding medium for electron microscopy

P304

1860-1870

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scholarly article

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10.1093/EMBOJ/17.7.1860

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7

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17

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1998-04-01T00:00:00Z

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51317680

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9524110

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1170533

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