LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program.
about
Contemporary murine models in preclinical astrocytoma drug developmentMicro-masters of glioblastoma biology and therapy: increasingly recognized roles for microRNAs.A Comparison of Exogenous Labels for the Histological Identification of Transplanted Neural Stem Cells.CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target.Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.ZEB1 Promotes Invasion in Human Fetal Neural Stem Cells and Hypoxic Glioma Neurospheres.Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain InhibitionGeroconversion: irreversible step to cellular senescenceThe chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicityEstablishment of human iPSC-based models for the study and targeting of glioma initiating cellsClinicopathological Characteristics of Patients with Gastric Cancer according to the Expression of LIN28A.Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survivalHypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma.Lin28A activates androgen receptor via regulation of c-myc and promotes malignancy of ER-/Her2+ breast cancer.The LIN28/let-7 Pathway in Cancer.Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii.EMT- and MET-related processes in nonepithelial tumors: importance for disease progression, prognosis, and therapeutic opportunities.Synthetic mRNA devices that detect endogenous proteins and distinguish mammalian cells.The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma.Let-7b inhibits the malignant behavior of glioma cells and glioma stem-like cells via downregulation of E2F2.Updates on the Molecular Pathology of Selected Ocular and Ocular Adnexal Tumors: Potential Targets for Future Therapy.The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma.Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells.Modeling astrocytoma pathogenesis in vitro and in vivo using cortical astrocytes or neural stem cells from conditional, genetically engineered mice.Dovitinib enhances temozolomide efficacy in glioblastoma cells.DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets.A Rapid Induction Mechanism for Lin28a in Trophic Responses.Identifying survival-associated modules from the dysregulated triplet network in glioblastoma multiforme.Embryonal tumor with multilayered rosettes (ETMR): signed, sealed, delivered ….The Role of Wnt Signal in Glioblastoma Development and Progression: A Possible New Pharmacological Target for the Therapy of This Tumor.The TORC1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity.Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum.Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties.Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro.HMGA2 promotes glioma invasion and poor prognosis via a long-range chromatin interaction.MicroRNA (miR) 125b regulates cell growth and invasion in pediatric low grade glioma
P2860
Q27026937-BDB7D180-7C6C-400B-8DDF-CA6E0968C9B4Q30405560-EDA67FBA-E385-4256-A2B2-F800E7C13505Q32184218-1827BF9F-8952-4A00-85C1-1DD4879EE428Q34157312-37503EAF-804A-41C2-A7BE-B72124561DB4Q35550199-5F247A90-4DE2-442E-8341-6792FCCAB086Q35590388-1F111C49-14F2-4677-9D5D-FF2C02CCF109Q35752332-411FA708-A145-4771-9DD1-FC1738F4CBB6Q36130555-967F72DF-D000-42AE-B17D-C7B8E4CEE333Q36186369-4B991311-910C-4974-9BCD-3A78D4267642Q36416243-FF1F4690-749F-4D57-9D5D-B132A7391414Q36611096-11F8E465-DC16-4FC7-9B1D-A60959684408Q37213507-9387C7C7-7D0E-4073-993A-EFA4483CB149Q37299271-3CEBB72F-1012-41AB-A522-27EE1EF78AC3Q37565283-67A998D3-612D-4717-A3B3-9284355CCCD2Q37645034-C1C5166C-98E9-425D-9BC1-7514E634CD94Q37723361-8BB863ED-267B-4906-9441-160572208CAEQ38613674-D27F4ED8-194C-4798-AE42-A3874119F8E5Q38677439-52BDCE09-0ADC-44CD-95E9-8E02BADC1D5DQ38681719-989304F0-B059-4333-BD9C-D774022AF042Q38705818-9509D482-83B9-4BD5-822E-B0BA427EF343Q38752222-65B0DC5F-73AE-4ACF-8A6D-094CC5F81898Q38766864-0F101E80-25E6-4DB4-A292-DE0CEC90F265Q38776367-8D68A63C-0357-45BD-A213-935E63B3393DQ38848185-13A98CCD-D2EB-4F91-9DC4-359B498BDF2CQ38963855-49EE2E40-6E48-496F-A0F7-DF902D0D8A4EQ40214485-4F63E2FD-D7FA-4648-A400-BC6D965510A6Q41366975-EA0D7F64-19A5-456F-9CA4-94A78D881ECCQ42504892-374F602D-D995-47B1-8F66-C6293C60B7A0Q48320688-D8EF61B5-9234-4978-BAED-E10F53C08731Q48665831-B33235B1-E1E0-4F3A-9B5C-E76435F174EDQ49804881-08F852F0-6C68-480E-BEFA-AD5625CA5F46Q52092512-D1E37838-5C5F-46CB-A811-C9EACA89A316Q52142487-E08FBC92-B0F3-4F95-904F-A439865CEF3DQ55106988-BC4AABD3-3FFF-483A-847F-D85601A85DD2Q55347904-F56239E1-E54E-42E2-A21C-0B4B60B3CD1EQ55457174-CB1E9C08-A24C-4385-98EF-72346BF10275Q58730599-DCF7A406-47CB-46A4-9990-91B3B112BB2F
P2860
LIN28A facilitates the transformation of human neural stem cells and promotes glioblastoma tumorigenesis through a pro-invasive genetic program.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
LIN28A facilitates the transfo ...... pro-invasive genetic program.
@en
type
label
LIN28A facilitates the transfo ...... pro-invasive genetic program.
@en
prefLabel
LIN28A facilitates the transfo ...... pro-invasive genetic program.
@en
P2093
P2860
P50
P356
P1433
P1476
LIN28A facilitates the transfo ...... a pro-invasive genetic program
@en
P2093
Anand K D Rajan
Brent A Orr
Guido Nikkhah
Isabella Taylor
Jarek Maciaczyk
Marianne Hütt-Cabezas
Melanie Weingart
Ulf Kahlert
Yazmin Odia
P2860
P304
P356
10.18632/ONCOTARGET.1131
P407
P577
2013-07-01T00:00:00Z