Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. - Wikidata - wikimedia - TriplyDB

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

http://www.wikidata.org/entity/Q41978909

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Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z Guidelines for the use and interpretation of assays for monitoring autophagy The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease Laforin, the most common protein mutated in Lafora disease, regulates autophagy PI(5)P regulates autophagosome biogenesis PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex Autophagy in ageing and ageing-associated diseases Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol The autophagy-lysosomal system in subarachnoid haemorrhage New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain Interactions between Autophagy and Bacterial Toxins: Targets for Therapy?The role of autophagy in the pathogenesis of diabetic nephropathy Capitalizing on the autophagic response for treatment of liver disease caused by alpha-1-antitrypsin deficiency and other genetic diseases Autophagy and neurodegeneration Protein homeostasis as a therapeutic target for diseases of protein conformation Inhibition of human immunodeficiency virus type-1 through autophagy Autophagy modulation as a potential therapeutic target for diverse diseases Targeting autophagy for the treatment of liver diseases Therapeutic targeting of autophagy in neurodegenerative and infectious diseases Autophagy modulation as a target for anticancer drug discovery Protein degradation pathways in Parkinson's disease: curse or blessing The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis Cell death and autophagy in tuberculosis Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases How Parkinsonian toxins dysregulate the autophagy machinery Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization Antioxidant Treatment and Induction of Autophagy Cooperate to Reduce Desmin Aggregation in a Cellular Model of Desminopathy Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1 Methods in mammalian autophagy research Autophagy and the integrated stress response Plasma membrane contributes to the formation of pre-autophagosomal structures New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.

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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

http://www.wikidata.org/entity/Q41978909

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

@zh-cn

name

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

@en

type

label

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

@en

prefLabel

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

@en

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Nature Chemical Biology

P1476

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

@en

P2093

Andrea Williams

http://www.w3.org/2001/XMLSchema#string

Angeleen Fleming

http://www.w3.org/2001/XMLSchema#string

David C Rubinsztein

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Dean Pask

http://www.w3.org/2001/XMLSchema#string

Evangelia K Ttofi

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Farah H Siddiqi

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Luca Jahreiss

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Paul Cuddon

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Paul Goldsmith

http://www.w3.org/2001/XMLSchema#string

Rodrigo Andres Floto

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P2860

Regulation of autophagy by the inositol trisphosphate receptor

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons

The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae.

The calpain system

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Inhibition of phospholipase C-epsilon by Gi-coupled receptors

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

Phospholipase C(epsilon): a novel Ras effector

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295-305

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scholarly article

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10.1038/NCHEMBIO.79

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5

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4

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2008-05-01T00:00:00Z

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5460530

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1041084532

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18391949

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Huntington disease

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2635566

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