Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury - Wikidata - wikimedia - TriplyDB

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

http://www.wikidata.org/entity/Q41982755

about

Generation and activation of multiple dimeric transcription factors within the NF-kappaB signaling system Role of T cell-nuclear factor κB in transplantation The NF-κB subunit RelA/p65 is dispensable for successful liver regeneration after partial hepatectomy in mice IKK mediates ischemia-induced neuronal death IKK2 inhibition attenuates laser-induced choroidal neovascularization IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.Mitochondrial glutathione, a key survival antioxidant.Oncogenic activation of NF-kappaB.Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species.SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways.Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis.Divergent roles of superoxide and nitric oxide in liver ischemia and reperfusion injury.Silencing of long noncoding RNA AK139328 attenuates ischemia/reperfusion injury in mouse livers Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration NF-κB and STAT3 - key players in liver inflammation and cancer Balance of inflammatory pathways and interplay of immune cells in the liver during homeostasis and injury.Cholestasis protects the liver from ischaemic injury and post-ischaemic inflammation in the mouse NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma.IKK biology.Cell death and cell death responses in liver disease: mechanisms and clinical relevance Use of a hanging-weight system for liver ischemia in mice.Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways.Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.V-PYRRO/NO downregulates mRNA expression levels of leukotriene C4 synthase during hepatic ischemia reperfusion injury in rats via inhibition of the nuclear factor-κB activation pathway p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure Hypothesis: Targeted Ikkβ deletion upregulates MIF signaling responsiveness and MHC class II expression in mouse hepatocytes.Targeted deletion of hepatocyte Ikkbeta confers growth advantages.Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion.Age-related decrease in proteasome expression contributes to defective nuclear factor-kappaB activation during hepatic ischemia/reperfusion NF-kappaB in liver diseases: a target for drug therapy.Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways.Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production.Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune Process.Role of nuclear factor kappaB in liver health and disease.NF-κB and STAT3 signaling hubs for lung innate immunity.Hepatic ischemia-reperfusion injury and therapeutic strategies to alleviate cellular damage.Tumor necrosis factor-α in liver ischemia/reperfusion injury.NF-κB signaling in prostate cancer: a promising therapeutic target?Targeting kinases for the treatment of inflammatory diseases.

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P2860

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

http://www.wikidata.org/entity/Q41982755

description

2005 nî lūn-bûn

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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2005年论文

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2005年论文

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name

Deletion of IKK2 in hepatocyte ...... om ischemia/reperfusion injury

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type

label

Deletion of IKK2 in hepatocyte ...... om ischemia/reperfusion injury

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prefLabel

Deletion of IKK2 in hepatocyte ...... om ischemia/reperfusion injury

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Journal of Clinical Investigation

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Deletion of IKK2 in hepatocyte ...... om ischemia/reperfusion injury

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P2093

Andreas Meyer zu Vilsendorf

http://www.w3.org/2001/XMLSchema#string

Christian Trautwein

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David A Brenner

http://www.w3.org/2001/XMLSchema#string

Mark Schmidt-Supprian

http://www.w3.org/2001/XMLSchema#string

Michael P Manns

http://www.w3.org/2001/XMLSchema#string

Tom Luedde

http://www.w3.org/2001/XMLSchema#string

Torsten Wüstefeld

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Ulrike Assmus

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P2860

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

Identification and characterization of an IkappaB kinase

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

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849-859

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10.1172/JCI23493

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4

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P478

115

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Manolis Pasparakis

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2005-03-17T00:00:00Z

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15776110

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reperfusion injury

P932

1064982

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