3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells
about
Heterochromatin remodeling by CDK12 contributes to learning in Drosophila.The role of TREX in gene expression and diseaseCracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFbInhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus.Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer.Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processingExpression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing.Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development.P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection.Localization of RNAPII and 3' end formation factor CstF subunits on C. elegans genes and operons.Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitorsThe histone variant H2A.Z promotes efficient cotranscriptional splicing in S. cerevisiae.Coordination of RNA Polymerase II Pausing and 3' End Processing Factor Recruitment with Alternative Polyadenylation.Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes.Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD.Polyadenylation site selection: linking transcription and RNA processing via a conserved carboxy-terminal domain (CTD)-interacting protein.The pol II CTD: new twists in the tail.Inhibitors of cyclin-dependent kinases as cancer therapeutics.CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.The emerging roles of CDK12 in tumorigenesis.Salt Stress and CTD PHOSPHATASE-LIKE4 Mediate the Switch between Production of Small Nuclear RNAs and mRNAs.CDK regulation of transcription by RNAP II: Not over 'til it's over?Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity.Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription.Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation.A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II
P2860
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P2860
3' end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
3' end formation of pre-mRNA a ...... rocally coupled in human cells
@en
type
label
3' end formation of pre-mRNA a ...... rocally coupled in human cells
@en
prefLabel
3' end formation of pre-mRNA a ...... rocally coupled in human cells
@en
P2860
P356
P1433
P1476
3' end formation of pre-mRNA a ...... rocally coupled in human cells
@en
P2093
Lee Davidson
Steven West
P2860
P304
P356
10.1101/GAD.231274.113
P50
P577
2014-01-29T00:00:00Z