Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.
about
The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signalingApplications of snake venom components to modulate integrin activities in cell-matrix interactionsDirect binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signalingIntegrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phopholipase A2 and impact on oligodendrocyte deathThe chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin αvβ3-dependent pathway.CC-PLA2-1 and CC-PLA2-2, two Cerastes cerastes venom-derived phospholipases A2, inhibit angiogenesis both in vitro and in vivo.Varespladib methyl in cardiovascular disease.Secreted PLA2 induces proliferation in astrocytoma through the EGF receptor: another inflammation-cancer link.Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3.Aberrant methylation of the M-type phospholipase A(2) receptor gene in leukemic cellsPhospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease.Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1.The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action.Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein.Phospholipase A2 structure/function, mechanism, and signaling.Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival.sPLA2-IIa is an inflammatory mediator when the ocular surface is compromisedRole of phospholipase A2s and lipid mediators in secondary damage after spinal cord injury.Group V Secreted Phospholipase A2 Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils.Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human Group IIA phospholipase A2.The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis.Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding.Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.Direct binding to integrins and loss of disulfide linkage in interleukin-1β (IL-1β) are involved in the agonistic action of IL-1β.Secreted Phospholipase A2 Type IIA (sPLA2-IIA) Activates Integrins in an Allosteric Manner.
P2860
Q24310890-968C8DB5-BADB-486D-A7A8-1206411D4996Q27011302-1516F057-D308-45CB-A15C-3E3148C2FD27Q28116711-FCC3A7CE-5C04-4759-9923-98EAF50B4F46Q28119172-E34BB12D-2EB2-4780-ABF4-FAD305272395Q30943736-3CE73749-9C13-4145-9E77-28F78018C17FQ31160040-0AC00BDF-B951-4BB5-85A0-A62292E084FDQ33393200-53554AE0-EA99-489E-AE4F-684B1B680A71Q33530304-E8E39B7B-DA0D-4206-A2A8-B5E1266D3F7DQ34135420-CFFEABA2-AF1A-4B17-B077-DC0CC857AD34Q34480613-1169D46C-1571-42EA-A768-622398ACC6E2Q34481371-494B4203-9B4F-4B29-B8E2-46A0988FE61DQ34502726-7CC7102D-08CC-4E8D-A8BE-CEC64ED1F96BQ34679377-259E057C-3A6C-47BF-AE1F-9BF14CDF3C24Q34776384-4BBC74F2-067D-44BF-A19B-DE51CD0A5407Q34801388-564DEFA2-C4B5-4DEA-AF93-8B5C6FECCC39Q35138588-560F9BEA-C92D-47AB-AF0B-15B4EEA38257Q35604546-BB902C7B-BD11-45B7-AEC3-97917C02B361Q37326136-A4F20BF8-F05A-4682-89BB-2BD1C2A08EC2Q37367844-160EA618-4CFF-46E0-BCC8-D3F967F50758Q37726033-18608C5A-0BD4-491E-8F51-1236245395CCQ38009737-977D52D0-C869-4F4D-AA85-3A2CDF5769CCQ38811622-904FBCF7-AC23-49AD-9A81-BCBEF015DD4BQ39038055-6B20828C-62B0-4DAC-9772-1D1988701513Q41059246-90DB0688-79FE-43E5-A06E-581F9E690D00Q41508882-39159AD7-F1EB-45E4-A72A-381D265475F5Q41617811-B87F5AAC-D784-4E38-8501-BF3863133372Q46979263-F251F17D-73C9-4248-AE16-D3F15DCDE8F8Q51316539-809D6DBB-6198-4471-AA88-3FD92C4B7F6E
P2860
Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Pro-inflammatory secretory pho ...... an integrin-dependent manner.
@en
type
label
Pro-inflammatory secretory pho ...... an integrin-dependent manner.
@en
prefLabel
Pro-inflammatory secretory pho ...... an integrin-dependent manner.
@en
P2093
P2860
P356
P1476
Pro-inflammatory secretory pho ...... an integrin-dependent manner.
@en
P2093
Case Hoogland
Chun-Yi Wu
Fu-Tong Liu
Jun Saegusa
Nobuaki Akakura
Yoko K Takada
P2860
P304
26107-26115
P356
10.1074/JBC.M804835200
P407
P577
2008-07-17T00:00:00Z