Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk. - Wikidata - wikimedia - TriplyDB

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

http://www.wikidata.org/entity/Q41985591

about

Nuclear receptors and AMPK: can exercise mimetics cure diabetes?Bile acids are nutrient signaling hormones Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis Metformin and the gastrointestinal tract Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats.Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor.Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure.Metformin as a Tool to Target Aging.Posttranslational Modifications of Lipid-Activated Nuclear Receptors: Focus on Metabolism.Retinoid X Receptors Intersect the Molecular Clockwork in the Regulation of Liver Metabolism.Metformin: a review of its potential indications.In vivo therapeutic effect of combination treatment with metformin and Scutellaria baicalensis on maintaining bile acid homeostasis Alteration of FXR phosphorylation and sumoylation in liver in the development of adult catch-up growth.Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats.The logic of transcriptional regulator recruitment architecture at cis-regulatory modules controlling liver functions.Towards natural mimetics of metformin and rapamycin.Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment.Bile acids in glucose metabolism in health and disease.The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: potential hypoglycaemic and anti-inflammatory effects.Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.β-Catenin regulation of farnesoid X receptor signaling and bile acid metabolism during murine cholestasis.AMPK improves gut epithelial differentiation and barrier function via regulating Cdx2 expression.Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis.Allosteric modulation of the farnesoid X receptor by a small molecule

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P2860

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

http://www.wikidata.org/entity/Q41985591

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

2014年论文

@zh

2014年论文

@zh-cn

name

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

@en

type

label

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

@en

prefLabel

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

@en

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P1433

Journal of Clinical Investigation

P1476

Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk

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P2093

Alain Van Dorsselaer

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Albert K Groen

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Alexandre Patrice

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Anthony Lucas

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Céline Gheeraert

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Emmanuel Bouchaert

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Fleur Lien

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Geoffrey Porez

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Hélène Diemer

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Janne Prawitt

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P2860

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

The regulation of AMP-activated protein kinase by phosphorylation

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1

Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1

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1037-1051

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10.1172/JCI68815

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3

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124

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Francois Pattou

Hélène Dehondt

Alexandre Berthier

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2014-02-17T00:00:00Z

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24531544

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3938262

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