Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
about
Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonistStructural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+.The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.Carrier-mediated delivery of metabotrophic glutamate receptor ligands to the central nervous system: structural tolerance and potential of the L-system amino acid transporter at the blood-brain barrierCharacterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranesCharacterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices.Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1.Antagonist activity of alpha-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells.Blunted cystine-glutamate antiporter function in the nucleus accumbens promotes cocaine-induced drug seeking.A specific role for group I mGluRs in hippocampal LTP and hippocampus-dependent spatial learning.Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5.Pharmacology of (S)-homoquisqualic acid and (S)-2-amino-5-phosphonopentanoic acid [(S)-AP5] at cloned metabotropic glutamate receptors.Proline-catalysed asymmetric amination of alpha,alpha-disubstituted aldehydes: synthesis of configurationally stable enantioenriched alpha-aminoaldehydes.Metabotropic glutamate receptor antagonists selectively enhance responses of slowly adapting type I mechanoreceptors.Pattern-specific synaptic mechanisms in a multifunctional network. II. Intrinsic modulation by metabotropic glutamate receptors.Amino acid sensing in hypothalamic tanycytes via umami taste receptors.mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons.(+)-MCPG blocks induction of LTP in CA1 of rat hippocampus via agonist action at an mGluR group II receptor.Presynaptic origin of paired-pulse depression at climbing fibre-Purkinje cell synapses in the rat cerebellum.Activation of group III metabotropic glutamate receptors by endogenous glutamate protects against glutamate-mediated excitotoxicity in the hippocampus in vivo.
P2860
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P2860
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Structure-activity relationshi ...... c glutamate receptor subtypes.
@en
type
label
Structure-activity relationshi ...... c glutamate receptor subtypes.
@en
prefLabel
Structure-activity relationshi ...... c glutamate receptor subtypes.
@en
P2093
P2860
P1476
Structure-activity relationshi ...... c glutamate receptor subtypes.
@en
P2093
J C Watkins
N Sekiyama
S Nakanishi
P2860
P304
P356
10.1111/J.1476-5381.1996.TB15312.X
P407
P577
1996-04-01T00:00:00Z