Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia - Wikidata - wikimedia - TriplyDB

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

http://www.wikidata.org/entity/Q42011206

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Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins Role of Hedgehog Signaling Pathway in NASH Cilia functions in development Primary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengers C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins The primary cilium: a signalling centre during vertebrate development Trafficking to the primary cilium membrane.Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.Mechanism and evolution of cytosolic Hedgehog signal transduction Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.Clinical implications of hedgehog signaling pathway inhibitors The hedgehog/Gli signaling paradigm in prostate cancer T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms.Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response Hedgehog secretion and signal transduction in vertebrates.Ciliary Entry of the Hedgehog Transcriptional Activator Gli2 Is Mediated by the Nuclear Import Machinery but Differs from Nuclear Transport in Being Imp-α/β1-Independent Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.The relationship between sonic Hedgehog signaling, cilia, and neural tube defects Kif3a is necessary for initiation and maintenance of medulloblastoma.Activation of the hedgehog-signaling pathway in human cancer and the clinical implications.Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.Hedgehog signaling and gastrointestinal cancer The primary cilium as a Hedgehog signal transduction machine.Hedgehog signaling in skin cancers Basic biology and mechanisms of neural ciliogenesis and the B9 family.The Hedgehog signal transduction network.

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Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

http://www.wikidata.org/entity/Q42011206

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

@en

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

@nl

type

label

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

@en

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

@nl

prefLabel

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

@en

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

@nl

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J.YDBIO.2009.04.009

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Developmental Biology

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Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

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P2093

Aimin Liu

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Asa Kolterud

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Huiqing Zeng

http://www.w3.org/2001/XMLSchema#string

Jinping Jia

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Rune Toftgård

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Stephan Teglund

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P2860

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation

The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins

Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex

Suppressor of fused regulates Gli activity through a dual binding mechanism

Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia

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