The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
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The role for protein tyrosine phosphatase non-receptor type 22 in regulating intestinal homeostasisLower Affinity T Cells are Critical Components and Active Participants of the Immune ResponseThe role of T cell receptor signaling thresholds in guiding T cell fate decisionsAutoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signalingRole of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammationSuper-low dose endotoxin pre-conditioning exacerbates sepsis mortality.Small molecule inhibition of Csk alters affinity recognition by T cells.Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.CCR6(+) Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritisApoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus.CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells.PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection.Coeliac disease and rheumatoid arthritis: similar mechanisms, different antigens.The immune system as a self-centered network of lymphocytes.T Cell's Sense of Self: a Role of Self-Recognition in Shaping Functional Competence of Naïve T Cells.Vagal influences in rheumatoid arthritis.The PTPN22 R263Q polymorphism confers protection against systemic lupus erythematosus and rheumatoid arthritis, while PTPN22 R620W confers susceptibility to Graves' disease in a Mexican population.The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting.Two Strikes and You're Out? The Pathogenic Interplay of Coinhibitor Deficiency and Lymphopenia-Induced Proliferation.Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice.The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.Protein tyrosine phosphatase PTPN22 has dual roles in promoting pathogen versus homeostatic-driven CD8 T-cell responses.The functional PTPN22 C1858T polymorphism confers risk for rheumatoid arthritis in patients from Central Mexico.The W620 Polymorphism in PTPN22 Disrupts Its Interaction With Peptidylarginine Deiminase Type 4 and Enhances Citrullination and NETosis.Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 PhosphorylationLack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice.Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis.PTPN22 inhibition resets defective human central B cell toleranceAutoimmunity in 2014.Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.Updates in Lupus Genetics.Regulation of autoimmune and anti-tumour T-cell responses by PTPN22.
P2860
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P2860
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
The tyrosine phosphatase PTPN2 ...... om strong agonist TCR signals.
@en
The tyrosine phosphatase PTPN2 ...... om strong agonist TCR signals.
@nl
type
label
The tyrosine phosphatase PTPN2 ...... om strong agonist TCR signals.
@en
The tyrosine phosphatase PTPN2 ...... om strong agonist TCR signals.
@nl
prefLabel
The tyrosine phosphatase PTPN2 ...... om strong agonist TCR signals.
@en
The tyrosine phosphatase PTPN2 ...... om strong agonist TCR signals.
@nl
P2860
P50
P356
P1154
2-s2.0-84906322377
P1433
P1476
The tyrosine phosphatase PTPN2 ...... om strong agonist TCR signals.
@en
P2860
P2888
P304
P356
10.1038/NI.2958
P407
P5530
P577
2014-08-10T00:00:00Z
P6179
1007855487