Polycomb repressive complex 2 contributes to DNA double-strand break repair. - Wikidata - wikimedia - TriplyDB

Polycomb repressive complex 2 contributes to DNA double-strand break repair.

Polycomb repressive complex 2 contributes to DNA double-strand break repair.

http://www.wikidata.org/entity/Q42017606

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The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair Chromatin modifications during repair of environmental exposure-induced DNA damage: a potential mechanism for stable epigenetic alterations.Regulation and Role of EZH2 in Cancer The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancer Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila Loss of HP1 causes depletion of H3K27me3 from facultative heterochromatin and gain of H3K27me2 at constitutive heterochromatin.Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma.DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling.EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells.Targeting DNA Repair in Cancer: Beyond PARP Inhibitors.Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin Histone modifications in DNA damage response.Epigenetic silencing and activation of transcription: influence on the radiation sensitivity of glioma cell lines.Visualization of miniSOG Tagged DNA Repair Proteins in Combination with Electron Spectroscopic Imaging (ESI).Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage.Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity.HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.Express or repress? The transcriptional dilemma of damaged chromatin.Polycomb Repressor Complex 2 in Genomic Instability and Cancer Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition.Functional dissection of Drosophila melanogaster SUUR protein influence on H3K27me3 profile.Meta-analysis of DNA double-strand break response kinetics.CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair.EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma.EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer.Developmental epigenetic programming of adult germ cell death disease: Polycomb protein EZH2-miR-101 pathway.Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses.DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration.Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage.Histone methylation in DNA repair and clinical practice: new findings during the past 5-years.EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer

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P2860

Polycomb repressive complex 2 contributes to DNA double-strand break repair.

http://www.wikidata.org/entity/Q42017606

description

2013 nî lūn-bûn

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2013年論文

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2013年论文

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name

Polycomb repressive complex 2 contributes to DNA double-strand break repair.

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Polycomb repressive complex 2 contributes to DNA double-strand break repair.

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type

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Polycomb repressive complex 2 contributes to DNA double-strand break repair.

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Polycomb repressive complex 2 contributes to DNA double-strand break repair.

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Polycomb repressive complex 2 contributes to DNA double-strand break repair.

@en

Polycomb repressive complex 2 contributes to DNA double-strand break repair.

@nl

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Polycomb repressive complex 2 contributes to DNA double-strand break repair.

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Guy G Poirier

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Ismail Hassan Ismail

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Leah C Young

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Michael J Hendzel

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Stuart Campbell

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P2860

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

Role of histone H2A ubiquitination in Polycomb silencing

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27

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10.4161/CC.25795

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16

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