Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
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Qinghaosu (Artemisinin): The Price of SuccessArtemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole MorphologyRearrangements of organic peroxides and related processesArtemisinins: their growing importance in medicineArtemisinin directly targets malarial mitochondria through its specific mitochondrial activation.Fixed dose combination of arterolane and piperaquine: a newer prospect in antimalarial therapyThe lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesEfficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate dispersible tablets in paediatric patients with acute uncomplicated Plasmodium falciparum malaria: a phase II, multicentric, open-label study.Discovery, mechanisms of action and combination therapy of artemisininDevelopment and validation of a headspace gas chromatographic method for the determination of residual solvents in arterolane (RBx11160) maleate bulk drug.Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probesThe global pipeline of new medicines for the control and elimination of malariaMonoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate-Piperaquine Phosphate vs Artemether-Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and AfricaAccumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent.Malaria and iron: history and review.In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate.Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.Natural product and natural product derived drugs in clinical trials.Honoring antiparasitics: The 2015 Nobel Prize in Physiology or Medicine.Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).Challenges to replace ACT as first-line drug.Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials.In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains.Electron microscopical study to assess the in vitro effects of the synthetic trioxolane OZ78 against the liver fluke, Fasciola hepatica.Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects.Adult triclabendazole-resistant Fasciola hepatica: morphological changes in the tegument and gut following in vivo treatment with artemether in the rat model.
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P2860
Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
@en
Mechanism of antimalarial action of the synthetic trioxolane RBX11160
@nl
type
label
Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
@en
Mechanism of antimalarial action of the synthetic trioxolane RBX11160
@nl
prefLabel
Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
@en
Mechanism of antimalarial action of the synthetic trioxolane RBX11160
@nl
P2093
P2860
P356
P1476
Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
@en
P2093
Anne-Catrin Uhlemann
Hugues Matile
Leyla Y Bustamante
P2860
P304
P356
10.1128/AAC.01064-06
P407
P577
2006-12-04T00:00:00Z