Using distal-site mutations and allosteric inhibition to tune, extend, and narrow the useful dynamic range of aptamer-based sensors.
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Selection and Biosensor Application of Aptamers for Small MoleculesPrinciples of allosteric interactions in cell signalingAn Ionic 1,4-Bis(styryl)benzene-Based Fluorescent Probe for Mercury(II) Detection in Water via Deprotection of the Thioacetal GroupComplementary oligonucleotides regulate induced fit ligand binding in duplexed aptamers.Allosteric DNA nanoswitches for controlled release of a molecular cargo triggered by biological inputs.Principal factors that determine the extension of detection range in molecular beacon aptamer/conjugated polyelectrolyte bioassays.Rationally manipulating aptamer binding affinities in a stem-loop molecular beaconIntrinsic disorder as a generalizable strategy for the rational design of highly responsive, allosterically cooperative receptors.Recognition of nucleic acid junctions using triptycene-based molecules.Thermodynamic basis for engineering high-affinity, high-specificity binding-induced DNA clamp nanoswitches.Aptamers: active targeting ligands for cancer diagnosis and therapyYoctoliter thermometry for single-molecule investigations: a generic bead-on-a-tip temperature-control module.Artificial phosphorylation sites modulate the activity of a voltage-gated potassium channel.Triptycene-based small molecules modulate (CAG)·(CTG) repeat junctions.Real-time measurement of small molecules directly in awake, ambulatory animals.Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensorsSalt-mediated two-site ligand binding by the cocaine-binding aptamer.General Strategy to Introduce pH-Induced Allostery in DNA-Based Receptors to Achieve Controlled Release of Ligands.Rational design of a structure-switching DNA aptamer for potassium ions.Reagentless, Structure-Switching, Electrochemical Aptamer-Based Sensors.Electronic control of DNA-based nanoswitches and nanodevices.Allosterically tunable, DNA-based switches triggered by heavy metals.Bridgehead-Substituted Triptycenes for Discovery of Nucleic Acid Junction Binders.Using Nature's "Tricks" To Rationally Tune the Binding Properties of Biomolecular Receptors.Comprehensive profiling of the ligand binding landscapes of duplexed aptamer families reveals widespread induced fit.A modular clamp-like mechanism to regulate the activity of nucleic-acid target-responsive nanoswitches with external activators.Detection and identification of designer drugs by nanoparticle-based NMR chemosensing.Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure.Modulation of Charge Density of Cationic Conjugated Polyelectrolytes for Improving the FRET-Induced Sensory Signal with Enhanced On/Off RatioConjugated Polyelectrolyte and Aptamer Based Potassium Assay via Single- and Two-Step Fluorescence Energy Transfer with a Tunable Dynamic Detection Range
P2860
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P2860
Using distal-site mutations and allosteric inhibition to tune, extend, and narrow the useful dynamic range of aptamer-based sensors.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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name
Using distal-site mutations an ...... ange of aptamer-based sensors.
@en
Using distal-site mutations an ...... ange of aptamer-based sensors.
@nl
type
label
Using distal-site mutations an ...... ange of aptamer-based sensors.
@en
Using distal-site mutations an ...... ange of aptamer-based sensors.
@nl
prefLabel
Using distal-site mutations an ...... ange of aptamer-based sensors.
@en
Using distal-site mutations an ...... ange of aptamer-based sensors.
@nl
P2860
P356
P1476
Using distal-site mutations an ...... range of aptamer-based sensors
@en
P2093
Alessandro Porchetta
Alexis Vallée-Bélisle
P2860
P304
20601-20604
P356
10.1021/JA310585E
P407
P577
2012-12-13T00:00:00Z