Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9 - Wikidata - wikimedia - TriplyDB

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

http://www.wikidata.org/entity/Q42024304

about

Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot Advances in Autophagy Regulatory Mechanisms The crucial impact of lysosomes in aging and longevity Regulation of lysosomal ion homeostasis by channels and transporters The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Amino acid homeostasis and signalling in mammalian cells and organisms.The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission.From Krebs to clinic: glutamine metabolism to cancer therapy.Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.Multiple amino acid sensing inputs to mTORC1.Sestrin regulation of TORC1: Is Sestrin a leucine sensor?Potential therapeutic approaches for Angelman syndrome.An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication.The lysosome as a command-and-control center for cellular metabolism.Unsolved mysteries of Rag GTPase signaling in yeast.Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway mTOR function and therapeutic targeting in breast cancer.Rag GTPase in amino acid signaling.mTOR Signaling in Growth, Metabolism, and Disease.Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.Autophagy in the liver: functions in health and disease.Nutrient sensing and TOR signaling in yeast and mammals.Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment.Cell biology in China: Focusing on the lysosome.The Architecture of the Rag GTPase Signaling Network.Rags to riches: Amino acid sensing by the Rag GTPases in health and disease.Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.BORC coordinates encounter and fusion of lysosomes with autophagosomes.Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism.The amino acid transporter SLC38A9 regulates MTORC1 and autophagy.SNAT7 is the primary lysosomal glutamine exporter required for extracellular protein-dependent growth of cancer cells.SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.l-Citrulline Metabolism in Mice Augments CD4+ T Cell Proliferation and Cytokine Production In Vitro, and Accumulation in the Mycobacteria-Infected Lung.

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Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

http://www.wikidata.org/entity/Q42024304

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

@zh-cn

name

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

@en

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

@nl

type

label

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

@en

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

@nl

prefLabel

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

@en

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

@nl

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Molecular and Cellular Biology

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Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

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Christian Behrends

http://www.w3.org/2001/XMLSchema#string

Heide Marika Genau

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Jennifer Jung

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P2860

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

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2479-2494

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10.1128/MCB.00125-15

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14

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35

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2015-05-11T00:00:00Z

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4475919

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