SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells.
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Minicircle Mediated Gene Delivery to Canine and Equine Mesenchymal Stem Cells.Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno-Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor-β Gene Delivery.Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics.Sox9 potentiates BMP2-induced chondrogenic differentiation and inhibits BMP2-induced osteogenic differentiationLong-term expansion, enhanced chondrogenic potential, and suppression of endochondral ossification of adult human MSCs via WNT signaling modulation.Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes.Strategies to minimize hypertrophy in cartilage engineering and regeneration.New trends in articular cartilage repair.Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells.Inhibitory function of parathyroid hormone-related protein on chondrocyte hypertrophy: the implication for articular cartilage repairEffects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates.Cell-penetrating peptide (CPP)-conjugated proteins is an efficient tool for manipulation of human mesenchymal stromal cells.Advances and challenges in gene-based approaches for osteoarthritis.Use of tissue engineering strategies to repair joint tissues in osteoarthritis: viral gene transfer approaches.Tissue-engineering strategies to repair joint tissue in osteoarthritis: nonviral gene-transfer approaches.Viral vector-mediated transgenic cell therapy in regenerative medicine: safety of the process.TGF-β gene transfer and overexpression via rAAV vectors stimulates chondrogenic events in human bone marrow aspirates.Gene therapy for chondral and osteochondral regeneration: is the future now?Gene therapy for human osteoarthritis: principles and clinical translation.Impact of mechanical stimulation on the chondrogenic processes in human bone marrow aspirates modified to overexpress sox9 via rAAV vectors.Management of knee osteoarthritis. Current status and future trends.rAAV-mediated combined gene transfer and overexpression of TGF-β and SOX9 remodels human osteoarthritic articular cartilage.rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair.Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates upon rAAV-Mediated Gene Transfer and Overexpression of the Insulin-Like Growth Factor I.Gene Delivery Approaches for Mesenchymal Stem Cell Therapy: Strategies to Increase Efficiency and Specificity.Gene modification of mesenchymal stem cells and articular chondrocytes to enhance chondrogenesisDelivery of the Sox9 gene promotes chondrogenic differentiation of human umbilical cord blood-derived mesenchymal stem cells in an in vitro modelParathyroid Hormone-Induced Bone Marrow Mesenchymal Stem Cell Chondrogenic Differentiation and its Repair of Articular Cartilage Injury in RabbitsDetermination of effective rAAV-mediated gene transfer conditions to support chondrogenic differentiation processes in human primary bone marrow aspirates.Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo.Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cellsrAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ.Biomedical-grade, high mannuronic acid content (BioMVM) alginate enhances the proteoglycan production of primary human meniscal fibrochondrocytes in a 3-D microenvironmentThree years of Stem Cell Research & Therapy.Cartilage repair techniques in the knee: stem cell therapies.Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo.Adapted chondrogenic differentiation of human mesenchymal stem cells via controlled release of TGF-β1 from poly(ethylene oxide)-terephtalate/poly(butylene terepthalate) multiblock scaffolds.Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes.Characterization of Sox9-overexpressing human umbilical cord blood-derived mesenchymal stem cells-based engineered cartilage both in vitro and in vivo.Induction of mesenchymal stem cell chondrogenesis through sequential administration of growth factors within specific temporal windows.
P2860
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P2860
SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
SOX9 gene transfer via safe, s ...... human mesenchymal stem cells.
@en
SOX9 gene transfer via safe, s ...... human mesenchymal stem cells.
@nl
type
label
SOX9 gene transfer via safe, s ...... human mesenchymal stem cells.
@en
SOX9 gene transfer via safe, s ...... human mesenchymal stem cells.
@nl
prefLabel
SOX9 gene transfer via safe, s ...... human mesenchymal stem cells.
@en
SOX9 gene transfer via safe, s ...... human mesenchymal stem cells.
@nl
P2093
P2860
P356
P1476
SOX9 gene transfer via safe, s ...... human mesenchymal stem cells.
@en
P2093
Dieter Kohn
Gertrud Schmitt
Henning Madry
Jagadeesh K Venkatesan
Myriam Ekici
P2860
P2888
P356
10.1186/SCRT113
P577
2012-01-01T00:00:00Z
P5875
P6179
1034020292