G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.
about
G-CSF and GM-CSF in NeutropeniaOncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CMLShp2 activates Fyn and Ras to regulate RBL-2H3 mast cell activation following FcεRI aggregation.Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells.SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axisSH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in miceFunctions of the Lyn tyrosine kinase in health and diseaseLigand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization.Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy.Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable.Systems approach to phagocyte production and activation: neutrophils and monocytes.C/EBPα in normal and malignant myelopoiesis.EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells.Alternatively spliced, truncated GCSF receptor promotes leukemogenic properties and sensitivity to JAK inhibition.Severe congenital neutropenias.Enhanced MAPK signaling is essential for CSF3R-induced leukemia.Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice.CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AMLGab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.
P2860
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P2860
G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
G-CSF receptor activation of t ...... tment of the Shp2 phosphatase.
@en
G-CSF receptor activation of t ...... tment of the Shp2 phosphatase.
@nl
type
label
G-CSF receptor activation of t ...... tment of the Shp2 phosphatase.
@en
G-CSF receptor activation of t ...... tment of the Shp2 phosphatase.
@nl
prefLabel
G-CSF receptor activation of t ...... tment of the Shp2 phosphatase.
@en
G-CSF receptor activation of t ...... tment of the Shp2 phosphatase.
@nl
P2093
P2860
P1433
P1476
G-CSF receptor activation of t ...... tment of the Shp2 phosphatase.
@en
P2093
Benjamin G Neel
Gen-Sheng Feng
Muneyoshi Futami
Quan-Sheng Zhu
Seth J Corey
Zakary L Whichard
P2860
P304
P356
10.1182/BLOOD-2009-12-261636
P407
P577
2011-06-02T00:00:00Z