about
Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression.Recurrent/moderate hypoglycemia induces hippocampal dendritic injury, microglial activation, and cognitive impairment in diabetic rats.Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase.Heat-shock protein protection.Mitochondrial dysfunction induced by nuclear poly(ADP-ribose) polymerase-1: a treatable cause of cell death in stroke.Targeting microglial activation in stroke therapy: pharmacological tools and gender effects.NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal deathOpposing effects of glucose on stroke and reperfusion injury: acidosis, oxidative stress, and energy metabolism.Robust neuroprosthetic control from the stroke perilesional cortex.NADPH oxidase-2: linking glucose, acidosis, and excitotoxicity in stroke.Glucose and NADPH oxidase drive neuronal superoxide formation in stroke.Astrocyte influences on ischemic neuronal death.Novel modulators of poly(ADP-ribose) polymerase.Players in the PARP-1 cell-death pathway: JNK1 joins the cast.Sirtuins in neurodegenerative diseases: an update on potential mechanisms.Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase.Pyruvate protects against experimental stroke via an anti-inflammatory mechanism.Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.A systematic survey of lipids across mouse tissues.Inhibition of mitochondrial function in astrocytes: implications for neuroprotection.Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands.Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress.Glucose, acid, and aspartate: Friends and foes of the axonThe poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death.Zinc triggers microglial activationHypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.EAAC1 gene deletion alters zinc homeostasis and exacerbates neuronal injury after transient cerebral ischemia.Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains.Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes.N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-/- mouseDigitally quantifying cerebral hemorrhage using Photoshop and Image J.INTRODUCTION: Immune mechanisms of neurodegenerationAstrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity.Activation of glutamate uptake by guanosine in primary astrocyte cultures.Astrocyte glutamate uptake during chemical hypoxia in vitro.Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices.NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes.Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Raymond A Swanson
@ast
Raymond A Swanson
@en
Raymond A Swanson
@es
Raymond A Swanson
@nl
Raymond A Swanson
@sl
type
label
Raymond A Swanson
@ast
Raymond A Swanson
@en
Raymond A Swanson
@es
Raymond A Swanson
@nl
Raymond A Swanson
@sl
prefLabel
Raymond A Swanson
@ast
Raymond A Swanson
@en
Raymond A Swanson
@es
Raymond A Swanson
@nl
Raymond A Swanson
@sl
P106
P21
P31
P496
0000-0002-3664-5359