Two distinct genetic loci regulating class II gene expression are defective in human mutant and patient cell lines.
about
An isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DPSpecific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding proteinRegulation of the class II-associated invariant chain gene in normal and mutant B lymphocytes.B-cell-specific enhancer activity of conserved upstream elements of the class II major histocompatibility complex DQB geneConserved upstream sequences of human class II major histocompatibility genes enhance expression of class II genes in wild-type but not mutant B-cell lines.Reversion of a transcriptionally defective MHC class II-negative human B-cell mutantThe MHC class II E beta promoter: a complex arrangement of positive and negative elements determines B cell and interferon-gamma (IFN-gamma) regulated expression.Deficient antigen-presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome.Molecular characterization of major histocompatibility complex class II gene expression and demonstration of antigen-specific T cell response indicate a new phenotype in class II-deficient patients.Genetic evidence for a new type of major histocompatibility complex class II combined immunodeficiency characterized by a dyscoordinate regulation of HLA-D alpha and beta chains.An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivatorClass II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysisThe MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators.Promoter accessibility within the environment of the MHC is affected in class II-deficient combined immunodeficiency.Cooperativity between the J and S elements of class II major histocompatibility complex genes as enhancers in normal and class II-negative patient and mutant B cell lines.Reactivation of a major histocompatibility complex class II gene in mouse plasmacytoma cells and mouse T cells.Transcription analysis of class II human leukocyte antigen genes from normal and immunodeficient B lymphocytes, using polymerase chain reaction
P2860
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P2860
Two distinct genetic loci regulating class II gene expression are defective in human mutant and patient cell lines.
description
1988 nî lūn-bûn
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1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
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1988年学术文章
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1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
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1988年學術文章
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1988年學術文章
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name
Two distinct genetic loci regu ...... mutant and patient cell lines.
@en
Two distinct genetic loci regu ...... mutant and patient cell lines.
@nl
type
label
Two distinct genetic loci regu ...... mutant and patient cell lines.
@en
Two distinct genetic loci regu ...... mutant and patient cell lines.
@nl
prefLabel
Two distinct genetic loci regu ...... mutant and patient cell lines.
@en
Two distinct genetic loci regu ...... mutant and patient cell lines.
@nl
P2093
P2860
P1433
P1476
Two distinct genetic loci regu ...... mutant and patient cell lines.
@en
P2093
P2860
P304
P407
P577
1988-07-01T00:00:00Z