Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide.
about
Taurine: the appeal of a safe amino acid for skeletal muscle disordersIncreased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.Toward precision medicine in myotonic syndromes.Combined modifications of mexiletine pharmacophores for new lead blockers of Na(v)1.4 channels.Dual Action of Mexiletine and Its Pyrroline Derivatives as Skeletal Muscle Sodium Channel Blockers and Anti-oxidant Compounds: Toward Novel Therapeutic Potential.Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations.Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective.The anti-convulsants lacosamide, lamotrigine, and rufinamide reduce myotonia in isolated human and rat skeletal muscle.Identification of Mepenzolate Derivatives With Long-Acting Bronchodilatory Activity.
P2860
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P2860
Searching for novel anti-myotonic agents: pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide.
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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name
Searching for novel anti-myoto ...... clic derivatives of tocainide.
@en
Searching for novel anti-myoto ...... clic derivatives of tocainide.
@nl
type
label
Searching for novel anti-myoto ...... clic derivatives of tocainide.
@en
Searching for novel anti-myoto ...... clic derivatives of tocainide.
@nl
prefLabel
Searching for novel anti-myoto ...... clic derivatives of tocainide.
@en
Searching for novel anti-myoto ...... clic derivatives of tocainide.
@nl
P2093
P2860
P50
P1476
Searching for novel anti-myoto ...... clic derivatives of tocainide.
@en
P2093
Alessia Carocci
Alessia Catalano
Marilena Muraglia
P2860
P356
10.1016/J.NMD.2011.07.001
P577
2011-07-29T00:00:00Z