Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.
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Rule-based cell systems model of aging using feedback loop motifs mediated by stress responsesAdipose tissue endothelial cells from obese human subjects: differences among depots in angiogenic, metabolic, and inflammatory gene expression and cellular senescenceNO signaling and S-nitrosylation regulate PTEN inhibition in neurodegenerationObesity altered T cell metabolism and the response to infection.Chronic high fat diet induces cardiac hypertrophy and fibrosis in mice.A mouse model of diet-induced obesity and insulin resistanceChronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease.Mammalian target of rapamycin (mTOR) inhibitors: potential uses and a review of haematological adverse effects.Endothelial PGC-1α mediates vascular dysfunction in diabetes.Rictor is an independent prognostic factor for endometrial carcinoma.Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.Fat tissue, aging, and cellular senescence.Fasting mitigates immediate hypersensitivity: a pivotal role of endogenous D-beta-hydroxybutyrate.Accelerated and exacerbated effects of high dietary fat on neuronal damage induced by transient cerebral ischemia in the gerbil septum.p16INK4a reporter mice reveal age-promoting effects of environmental toxicantsObesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation.Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regenerationPKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemiaThe synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcoholInterleukin-7 inhibits tumor-induced CD27-CD28- suppressor T cells: implications for cancer immunotherapy.Role of p38 mitogen-activated protein kinase in vascular endothelial aging: interaction with Arginase-II and S6K1 signaling pathwaySingle rapamycin administration induces prolonged downward shift in defended body weight in ratsThe most important tasks for peer reviewers evaluating a randomized controlled trial are not congruent with the tasks most often requested by journal editors.NCI's provocative questions on cancer: some answers to ignite discussion.Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes.Mechanisms involved in the aging-induced vascular dysfunction.Comparison of rapamycin schedules in mice on high-fat diet.The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo.Method parameters' impact on mortality and variability in mouse stroke experiments: a meta-analysis.Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation.Cognitive rehabilitation reduces cognitive impairment and normalizes hippocampal CA1 architecture in a rat model of vascular dementia.Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions.Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.MTOR-driven quasi-programmed aging as a disposable soma theory: blind watchmaker vs. intelligent designer.Rapamycin extends life- and health span because it slows aging.Mammalian target of rapamycin signaling in cardiac physiology and disease.mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases.
P2860
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P2860
Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Obesity increases vascular sen ...... ic activation of Akt and mTOR.
@en
Obesity increases vascular sen ...... ic activation of Akt and mTOR.
@nl
type
label
Obesity increases vascular sen ...... ic activation of Akt and mTOR.
@en
Obesity increases vascular sen ...... ic activation of Akt and mTOR.
@nl
prefLabel
Obesity increases vascular sen ...... ic activation of Akt and mTOR.
@en
Obesity increases vascular sen ...... ic activation of Akt and mTOR.
@nl
P2093
P2860
P50
P1433
P1476
Obesity increases vascular sen ...... ic activation of Akt and mTOR.
@en
P2093
Hyung-Hwan Kim
James K Liao
Laura E Benjamin
Michael A Moskowitz
Naoki Sawada
Yukio Hiroi
P2860
P356
10.1126/SCISIGNAL.2000143
P577
2009-03-17T00:00:00Z