TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts

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Anti-TNF-alpha antibody attenuates subarachnoid hemorrhage-induced apoptosis in the hypothalamus by inhibiting the activation of Erk.

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Q54964419-58E1501D-5A32-4C60-94CB-6DAE506CAE1F

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TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts

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TSC2/Rheb signaling mediates E ...... C1 activity in C2C12 myoblasts

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TSC2/Rheb signaling mediates E ...... C1 activity in C2C12 myoblasts

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TSC2/Rheb signaling mediates E ...... C1 activity in C2C12 myoblasts

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TSC2/Rheb signaling mediates E ...... C1 activity in C2C12 myoblasts

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TSC2/Rheb signaling mediates E ...... C1 activity in C2C12 myoblasts

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TSC2/Rheb signaling mediates E ...... C1 activity in C2C12 myoblasts

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TSC2/Rheb signaling mediates E ...... C1 activity in C2C12 myoblasts

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Mitsunori Miyazaki

http://www.w3.org/2001/XMLSchema#string

Tohru Takemasa

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P2860

Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

TSC2 mediates cellular energy response to control cell growth and survival

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

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424-433

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scholarly article

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10.1002/2211-5463.12195

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2017-01-30T00:00:00Z

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28286738

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myoblast

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5337893

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TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts

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TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts

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