Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
about
Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC ModelsFunctional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptorDefective regulation of the ryanodine receptor induces hypertrophy in cardiomyocytes.Arrhythmic effects of Epac-mediated ryanodine receptor activation in Langendorff-perfused murine hearts are associated with reduced conduction velocity.Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice.Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.Exome analysis identifies Brody myopathy in a family diagnosed with malignant hyperthermia susceptibilityAberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyteEssential Role of Calmodulin in RyR Inhibition by Dantrolene.Dantrolene prevents arrhythmogenic Ca2+ release in heart failureOxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia.Halothane modulation of skeletal muscle ryanodine receptors: dependence on Ca2+, Mg2+, and ATP.Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.The structural biology of ryanodine receptors.Ryanodine receptors: physiological function and deregulation in Alzheimer disease.Structural and functional interactions within ryanodine receptor.Emerging pathways driving early synaptic pathology in Alzheimer's disease.Quercetin as a fluorescent probe for the ryanodine receptor activity in Jurkat cells.CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.Epac-induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes.Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.Heat Stroke
P2860
Q28547114-73E7D3DE-DA42-4AA5-819F-1A91565B1985Q28584856-7F3E29EA-1E45-4D06-8F9E-59FADDF4A46BQ28589538-FD4E818D-C6CC-4036-819E-A5F311693BADQ33579906-9A4CC695-3A8D-4B1F-AD3C-3B72E37D42DCQ33845927-1F03A5F4-613D-4535-AB6C-691134621824Q34201123-B7267129-E66D-473D-9289-24A23E0EF659Q34752142-B02183C6-B9E1-49F1-99AD-1DD4904C9FECQ35000743-E861CEA0-866A-44AE-A9B1-67BFCA339C95Q35163032-CD76734D-80D2-4343-B861-564EE7937CEAQ35745969-88ADCA0C-851B-4217-9816-40CEF07F5327Q35879180-6FF6C97F-457C-4364-A195-DEB52F495033Q35931379-7270953E-1D3A-47B4-BB08-D56094731012Q36037969-A6EA09FE-E7F7-42F2-96F1-C33123213B3CQ36768338-40404CE5-6A90-4EA3-A104-A7BE27A1B06BQ37393446-44D9750F-D741-44BD-B15A-919572039C7AQ37904888-17566B1B-CFE9-4ADD-A74D-417C66461649Q38217975-098C9317-3B9F-43EA-9FD0-35E3836E564AQ38502051-179FBD77-7184-4F3B-BFC4-39F8BE6AD167Q38962140-A4C87BB3-DB6E-4F65-ABDE-A5CF81051AECQ39182929-F809367A-69F3-402B-A973-BBEBE1BE618BQ41112224-6FCCFC4F-CEEB-4D1C-A8D8-15A6186C5FF2Q47659040-F15325BE-A5F3-4397-8ACC-5A6B81EB5542Q52655119-8EEC852E-82BF-443A-AE14-ACAA7492B768Q56003963-1BE8B17C-A27E-4EEB-90A9-5B22FC9CAC4C
P2860
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
@en
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
@nl
type
label
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
@en
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
@nl
prefLabel
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
@en
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
@nl
P2093
P2860
P356
P1433
P1476
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor
@en
P2093
Hiromi Morimoto
Jerome Parness
Jianjie Ma
Kalanethee Paul-Pletzer
Leslie S Jimenez
Noriaki Ikemoto
Philip G Williams
Takeshi Yamamoto
P2860
P304
P356
10.1042/BJ20041336
P407
P577
2005-05-01T00:00:00Z