Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
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Crystal structure of human cytochrome P450 2D6Biochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traitsIntegrated structure- and ligand-based in silico approach to predict inhibition of cytochrome P450 2D6.Understanding the determinants of selectivity in drug metabolism through modeling of dextromethorphan oxidation by cytochrome P450.Efficicent (R)-phenylethanol production with enantioselectivity-alerted (S)-carbonyl reductase II and NADPH regeneration.Functional characterization of a first avian cytochrome P450 of the CYP2D subfamily (CYP2D49)New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications.Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.Quantum mechanical modeling: a tool for the understanding of enzyme reactions.Pharmacokinetics of dextromethorphan and its metabolites in horses following a single oral administration.Erectile Dysfunction Drugs Changed the Protein Expressions and Activities of Drug-Metabolising Enzymes in the Liver of Male Rats.Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulationsWhy is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.ChannelsDB: database of biomacromolecular tunnels and pores.AmineDB: large scale docking of amines with CYP2D6 and scoring for druglike properties--towards defining the scope of the chemical defense against foreign amines in humans.Metabolism ofN-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction pointsComputational prediction of drug binding and rationalisation of selectivity towards cytochromes P450Microsecond MD simulations of human CYP2D6 wild-type and five allelic variants reveal mechanistic insights on the function
P2860
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P2860
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Phe120 contributes to the regi ...... l dextromethorphan metabolite.
@en
Phe120 contributes to the regi ...... l dextromethorphan metabolite.
@nl
type
label
Phe120 contributes to the regi ...... l dextromethorphan metabolite.
@en
Phe120 contributes to the regi ...... l dextromethorphan metabolite.
@nl
prefLabel
Phe120 contributes to the regi ...... l dextromethorphan metabolite.
@en
Phe120 contributes to the regi ...... l dextromethorphan metabolite.
@nl
P2093
P2860
P50
P356
P1433
P1476
Phe120 contributes to the regi ...... el dextromethorphan metabolite
@en
P2093
C Roland Wolf
Carol A Kemp
Jack U Flanagan
Lesley A McLaughlin
Richard Ward
P2860
P304
P356
10.1042/BJ20040062
P407
P577
2004-06-01T00:00:00Z