Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.
about
Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.Natural product analogues: towards a blueprint for analogue-focused synthesis.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist.High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs.Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20' ethyl substituent.Cobalt bis(acetylacetonate)--butyl hydroperoxide-triethylsilane: a general reagent combination for the Markovnikov-selective hydrofunctionalization of alkenes by hydrogen atom transfer
P2860
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P2860
Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.
@en
Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.
@nl
type
label
Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.
@en
Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.
@nl
prefLabel
Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.
@en
Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.
@nl
P2093
P2860
P356
P1476
Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.
@en
P2093
Dale L Boger
Daniel M Brody
John C Lukesh
Manuela Brutsch
Oliver Allemann
P2860
P304
P356
10.1021/JACS.6B04330
P407
P577
2016-06-29T00:00:00Z