Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity.
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Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectivesArginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxationArginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthmaRole of nitric oxide and superoxide in allergen-induced airway hyperreactivity after the late asthmatic reaction in guinea-pigsArginase and pulmonary diseasesGlucocorticoids inhibit lipopolysaccharide-induced up-regulation of arginase in rat alveolar macrophagesArginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanismBone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.Modulation of the oscillatory mechanics of lung tissue and the oxidative stress response induced by arginase inhibition in a chronic allergic inflammation model.Nitric oxide in health and disease of the respiratory system.The therapeutic potential of drugs targeting the arginase pathway in asthma.Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.Nitric oxide: a promising methodological approach in airway diseases.Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.Arginase and arginine dysregulation in asthma.Heparin normalizes allergen-induced nitric oxide deficiency and airway hyperresponsivenessIncreased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium.Functional role and species-specific contribution of arginases in pulmonary fibrosis.Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.Comparative pharmacokinetics of N(ω)-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats.Decreased arginine bioavailability and increased serum arginase activity in asthma.Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma.Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.Increased arginase activity in cystic fibrosis airways.Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.Increased expression of arginase I and II in allergic nasal mucosa.Effect of Anti-IL17 Antibody Treatment Alone and in Combination With Rho-Kinase Inhibitor in a Murine Model of Asthma
P2860
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P2860
Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Modulation of cholinergic airw ...... endogenous arginase activity.
@en
Modulation of cholinergic airw ...... endogenous arginase activity.
@nl
type
label
Modulation of cholinergic airw ...... endogenous arginase activity.
@en
Modulation of cholinergic airw ...... endogenous arginase activity.
@nl
prefLabel
Modulation of cholinergic airw ...... endogenous arginase activity.
@en
Modulation of cholinergic airw ...... endogenous arginase activity.
@nl
P2093
P2860
P356
P1476
Modulation of cholinergic airw ...... y endogenous arginase activity
@en
P2093
P2860
P304
P356
10.1038/SJ.BJP.0703488
P407
P577
2000-08-01T00:00:00Z