Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole Carbamate

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Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice

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Q41592725-44DA43C9-62B5-4393-B5DC-F82A4CCD8299

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Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole Carbamate

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

@yue

2016年論文

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2016年論文

@zh-hk

2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

Identification of Novel Steroi ...... eterone 3β-Imidazole Carbamate

@en

Identification of Novel Steroi ...... eterone 3β-Imidazole Carbamate

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type

Item

label

Identification of Novel Steroi ...... eterone 3β-Imidazole Carbamate

@en

Identification of Novel Steroi ...... eterone 3β-Imidazole Carbamate

@nl

prefLabel

Identification of Novel Steroi ...... eterone 3β-Imidazole Carbamate

@en

Identification of Novel Steroi ...... eterone 3β-Imidazole Carbamate

@nl

P1476

Identification of Novel Steroi ...... eterone 3β-Imidazole Carbamate

@en

P2093

Andrew K Kwegyir-Afful

http://www.w3.org/2001/XMLSchema#string

Marlena S Martin

http://www.w3.org/2001/XMLSchema#string

Puranik Purushottamachar

http://www.w3.org/2001/XMLSchema#string

Senthilmurugan Ramalingam

http://www.w3.org/2001/XMLSchema#string

Vidya P Ramamurthy

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P2860

Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer

Cancer statistics, 2015

A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

CYP17 inhibitors for prostate cancer therapy

Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant.

17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response.

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells.

Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.

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708-713

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scholarly article

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10.1021/ACSMEDCHEMLETT.6B00137

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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Vincent C Njar

P577

2016-05-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

27437082

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P932

4948004

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Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole Carbamate

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P2860

Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole Carbamate

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

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P577

P698

P932

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P1476

P2093

P2860

P304

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P356

P433

P478

P50

P577

P698

P932