Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. - Wikidata - wikimedia - TriplyDB

Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial.

Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial.

http://www.wikidata.org/entity/Q42170455

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Lactate kinetics in sepsis and septic shock: a review of the literature and rationale for further research Early goal-directed resuscitation of patients with septic shock: current evidence and future directions How to choose the therapeutic goals to improve tissue perfusion in septic shock Septic Shock: Advances in Diagnosis and Treatment Sepsis-associated hyperlactatemia The effect of goal-directed therapy on mortality in patients with sepsis - earlier is better: a meta-analysis of randomized controlled trials Perioperative cardiovascular monitoring of high-risk patients: a consensus of 12 New tools for optimizing fluid resuscitation in acute pancreatitis Early non-invasive cardiac output monitoring in hemodynamically unstable intensive care patients: A multi-center randomized controlled trial Sepsis pathophysiology and anesthetic consideration Subcellular Energetics and Metabolism: Potential Therapeutic Applications.When to stop septic shock resuscitation: clues from a dynamic perfusion monitoring.A systematic review of implementation strategies for assessment, prevention, and management of ICU delirium and their effect on clinical outcomes.Predictors of unattempted central venous catheterization in septic patients eligible for early goal-directed therapy.Reclassifying the spectrum of septic patients using lactate: severe sepsis, cryptic shock, vasoplegic shock and dysoxic shock.Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis.Even mild hyperlactatemia is associated with increased mortality in critically ill patients Introducing intravascular microdialysis for continuous lactate monitoring in patients undergoing cardiac surgery: a prospective observational study Fluid volume, lactate values, and mortality in sepsis patients with intermediate lactate values Clinical year in review 2014: critical care medicine Fluid resuscitation in sepsis: reexamining the paradigm Inability to obtain deferred consent due to early death in emergency research: effect on validity of clinical trial results The effect of intra-abdominal hypertension incorporating severe acute pancreatitis in a porcine model Lactate as a hemodynamic marker in the critically ill Brazilian recommendations of mechanical ventilation 2013. Part 2.Deferred consent in a minimal-risk study involving critically ill subarachnoid hemorrhage patients Point of care blood gases with electrolytes and lactates in adult emergencies A new device for continuous assessment of gut perfusion: proof of concept on a porcine model of septic shock Outcomes and statistical power in adult critical care randomized trials Clinical assessment of peripheral perfusion to predict postoperative complications after major abdominal surgery early: a prospective observational study in adults.Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine.Clinical relevance of pulse pressure variations for predicting fluid responsiveness in mechanically ventilated intensive care unit patients: the grey zone approach.Prevalence of low central venous oxygen saturation in the first hours of intensive care unit admission and associated mortality in septic shock patients: a prospective multicentre study The impact of serial lactate monitoring on emergency department resuscitation interventions and clinical outcomes in severe sepsis and septic shock: an observational cohort study.Preload dependence indices to titrate volume expansion during septic shock: a randomized controlled trial.Update in acute lung injury and critical care 2010.Point-of-care testing in the overcrowded emergency department--can it make a difference?Predictors of mortality and prehospital monitoring limitations in blunt trauma patients.Efficacy of single-dose intravenous immunoglobulin administration for severe sepsis and septic shock.The Japanese guidelines for the management of sepsis.

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P2860

Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial.

http://www.wikidata.org/entity/Q42170455

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RCCM.200912-1918OC

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American Journal of Respiratory and Critical Care Medicine

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Alex P Lima

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F Jeanette Schoonderbeek

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Jasper van Bommel

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LACTATE study group

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P2860

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine

Early goal-directed therapy in the treatment of severe sepsis and septic shock

A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group

Acute liver failure: redefining the syndromes

Goal-directed medical therapy and point-of-care testing improve outcomes after congenital heart surgery

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008

A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group

The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma.

Persistent occult hypoperfusion is associated with a significant increase in infection rate and mortality in major trauma patients.

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock.

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