HIV fusion peptide and its cross-linked oligomers: efficient syntheses, significance of the trimer in fusion activity, correlation of beta strand conformation with membrane cholesterol, and proximity to lipid headgroups
about
Magic angle spinning NMR of virusesHIV gp41-mediated membrane fusion occurs at edges of cholesterol-rich lipid domains.Membrane protein structure and dynamics from NMR spectroscopy.Fusion activity of HIV gp41 fusion domain is related to its secondary structure and depth of membrane insertion in a cholesterol-dependent fashion.Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating.Origins of resistance to the HIVgp41 viral entry inhibitor T20.HIV fusion peptide penetrates, disorders, and softens T-cell membrane mimics.Cholesterol depletion disorganizes oocyte membrane rafts altering mouse fertilization.REDOR solid-state NMR as a probe of the membrane locations of membrane-associated peptides and proteins.Targeting HIV-1 gp41-induced fusion and pathogenesis for anti-viral therapyClosed and Semiclosed Interhelical Structures in Membrane vs Closed and Open Structures in Detergent for the Influenza Virus Hemagglutinin Fusion Peptide and Correlation of Hydrophobic Surface Area with Fusion CatalysisAssessment of RNA carrier function in peptide amphiphiles derived from the HIV fusion peptideA strong correlation between fusogenicity and membrane insertion depth of the HIV fusion peptide.Computer-Aided Approaches for Targeting HIVgp41.Comparative analysis of membrane-associated fusion peptide secondary structure and lipid mixing function of HIV gp41 constructs that model the early pre-hairpin intermediate and final hairpin conformations.Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41.HIV gp41 six-helix bundle constructs induce rapid vesicle fusion at pH 3.5 and little fusion at pH 7.0: understanding pH dependence of protein aggregation, membrane binding, and electrostatics, and implications for HIV-host cell fusion.Solid-state nuclear magnetic resonance measurements of HIV fusion peptide 13CO to lipid 31P proximities support similar partially inserted membrane locations of the α helical and β sheet peptide structures.Detection of closed influenza virus hemagglutinin fusion peptide structures in membranes by backbone (13)CO- (15)N rotational-echo double-resonance solid-state NMR.Solid-state NMR spectroscopy of the HIV gp41 membrane fusion protein supports intermolecular antiparallel β sheet fusion peptide structure in the final six-helix bundle statepH-dependent vesicle fusion induced by the ectodomain of the human immunodeficiency virus membrane fusion protein gp41: Two kinetically distinct processes and fully-membrane-associated gp41 with predominant β sheet fusion peptide conformation.Nuclear magnetic resonance evidence for retention of a lamellar membrane phase with curvature in the presence of large quantities of the HIV fusion peptide.Irregular structure of the HIV fusion peptide in membranes demonstrated by solid-state NMR and MD simulations.Molecular dynamics simulations and conductance studies of the interaction of VP1 N-terminus from Polio virus and gp41 fusion peptide from HIV-1 with lipid membranes.Efficient Fusion at Neutral pH by Human Immunodeficiency Virus gp41 Trimers containing the Fusion Peptide and Transmembrane Domain.Cholesterol induces uneven curvature of asymmetric lipid bilayers.Solid-state nuclear magnetic resonance (NMR) spectroscopy of human immunodeficiency virus gp41 protein that includes the fusion peptide: NMR detection of recombinant Fgp41 in inclusion bodies in whole bacterial cells and structural characterization o
P2860
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P2860
HIV fusion peptide and its cross-linked oligomers: efficient syntheses, significance of the trimer in fusion activity, correlation of beta strand conformation with membrane cholesterol, and proximity to lipid headgroups
description
2009 nî lūn-bûn
@nan
2009年の論文
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2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
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2009年學術文章
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name
HIV fusion peptide and its cro ...... proximity to lipid headgroups
@en
HIV fusion peptide and its cro ...... proximity to lipid headgroups
@nl
type
label
HIV fusion peptide and its cro ...... proximity to lipid headgroups
@en
HIV fusion peptide and its cro ...... proximity to lipid headgroups
@nl
prefLabel
HIV fusion peptide and its cro ...... proximity to lipid headgroups
@en
HIV fusion peptide and its cro ...... proximity to lipid headgroups
@nl
P2860
P356
P1433
P1476
HIV fusion peptide and its cro ...... proximity to lipid headgroups
@en
P2093
David P Weliky
P2860
P304
P356
10.1021/BI8015668
P407
P577
2009-01-01T00:00:00Z